EVALUATION OF THE EFFECTIVENESS OF USING LIPOSOMAL FORMS OF VITAMINS, USING VITAMIN C AS THE EXAMPLE

Аннотация

Витамин С является экзогенным соединением, необходимым для различных метаболических процессов; поэтому эффективная доставка имеет решающее значение для поддержания гомеостаза организма. Фармакокинетика витамина С и его низкие количества в обработанных пищевых продуктах требуют его постоянного добавления. В статье мы представляем обзор на новую липосомальную формулу витамина С, свободную от вредных органических растворителей. Формула была количественно охарактеризована с точки зрения ее химического состава и наноструктурирования. Инкапсуляция витаминов и минералов в липосомы помогает улучшить общую биодоступность. Ключевые слова: Липосома,фармакокинетика,биодоступность. Annotatsiya. S vitamini turli metabolik jarayonlar uchun zarur bo'lgan ekzogen birikma; shuning uchun samarali etkazib berish tananing gomeostazini saqlab qolish uchun juda muhimdir. S vitaminining farmakokinetikasi va qayta ishlangan oziq-ovqatlardagi past darajalari uni muntazam ravishda qo'shishni talab qiladi. Ushbu maqolada biz zararli organik erituvchilardan xoli C vitaminining yangi liposomal formulasini ko'rib chiqamiz. Formula kimyoviy tarkibi va nanostrukturasi bo'yicha miqdoriy jihatdan tavsiflangan. Liposomalardagi vitaminlar va minerallarni kapsulalash umumiy bioavailabilityni yaxshilashga yordam beradi. Kalitso'zlar: lipozoma,farmakokinetika. Today, the creation of new groups of drugs with improved pharmacokinetic properties is an important area of ​ ​ modern medicine. One of the areas of modern pharmacology is the method of drug delivery and their bioavailability. This article provides an overview of 98,7:ROTCAFTCAPMI.SECNEICS LACIDEM,5202, yraurbeF,5emuloV gro.srehsilbupcimedaca.www vitamin C in liposomal form, its delivery to organs and tissues, as well as possible side risks ofusing thisform of vitamin. Vitamin C is an important antioxidant, it protects organs and tissues from damage caused by free radicals by activating the body's defenses, enhances and accelerates the repair of wounds and scars. Vitamin C is a vital vitamin because it participates in the synthesis of hyaluronic acid, collagen and elastin, is a cofactor of minerals such as calcium, zinc, and also affects the synthesis of cholesterol. Vitamin C accelerates protein and carbohydrate metabolism. It is a powerful detoxifier, accelerating the removal of toxic substances from the body: lead, copper, mercury, vanadium. Vitamin C participates in detoxification processes in hepatocytes with the participation of cytochrome P 450. The vitamin participates in the synthesis of interferon, having a direct effect on immunomodulation processes. Vitamin C is also a cofactor in iron absorption, improving the absorption of iron from food byconverting theFe3+ ion toFe2+ withtheformation ofacomplex compound. Research is currently underway to determine the neuroprotective effects of ascorbic acid in Alzheimer's disease and the prevention of age-related cognitive decline. However, avoiding vitamin deficiency appears to have a more beneficial effect than taking large doses as supplements to a healthy diet. Vitamin C plays an important role in strengthening blood vessels, increasing the body's endurance, enhancing exercise tolerance. In plasma, it increases endothelium-dependent vasodilation and reduces extracellular oxidants from neutrophils. Vitamin C deficiency leads to the potentially fatal disease scurvy, a low immunity that can only be cured by taking the correct dose of vitamin C. Vitamin C is not synthesized or accumulated in the body, so it must be replenished regularly. Conventional forms of ascorbic acid are not fully absorbed, are quickly destroyed, and irritate the gastrointestinal mucosa. The main advantages of vitamin C enclosed in a liposomal shell are high bioavailability and protection of the digestive tract mucosa from irritation even when taking high doses. The liposomal shell consists of phospholipids, which serve as additional buildingmaterial fordamaged cell membranes. Vitamin C contained in food or dietary supplements is broken down in the stomach. But the highly acidic environment of hydrochloric acid can partially neutralize it. To help vitamin C survive in an acidic environment, its water-soluble molecule is encapsulated in a liposome. This fat capsule forms a protective shield around vitamin C, protecting it from acid and transporting it to the small intestine for further absorption. Since most fat digestion occurs in the small intestine, vitamin C is released there after enzymes from the gallbladder and pancreas help break down lipids. Liposomes are vesicles that simply mimic the highly complex cell membranes comprising lipid bilayers surrounding an aqueous core, which have attracted considerable attention for the delivery and protection of both hydrophilic and hydrophobic compounds such as vitamins due to their unique properties of biocompatibility and biodegradability. Accordingly, liposomes can promote the protection and activity of vitaminC. 98,7:ROT