PATHOLOGOMORPHOLOGICAL FEATURES OF THE PLACENTA OF DECEASED WOMEN DUE TO UTERINE HEMORRHAGE

Аннотация

В данной статье анализируются патологоморфологические особенности, наблюдаемые в плаценте у женщин, умерших вследствие маточного кровотечения. В ходе исследования были выявлены тромбозы, некротические изменения, фибриноидная дегенерация, атрофия ворсинок в кровеносных сосудах плаценты. Эти изменения стали причиной усиленного кровоизлияния и возникновения тяжелых патологических состояний в женском организме. Результаты исследования подчеркивают необходимость раннего выявления патологических состояний плаценты и необходимость проведения профилактических мероприятий. Данная работа имеет практическое значение для совершенствования методов диагностики и леченияопасных состоянийво время беременности. Ключевые слова: маточное кровотечение, плацентарная патология, патологоморфологические особенности, некроз, фибриноидная дегенерация, тромбоз, атрофияворсинок,осложнениябеременности. Uterine hemorrhage (uterine bleeding) is one of the most dangerous conditions for women's health and can be fatal in many cases. This process directly affects not only the general condition of the female organism, but also the structure of the placenta (placenta) during pregnancy. This article analyzes the pathologomorphological changes observed in the placenta offemales that diedueto uterine hemorrhage. Uterine hemorrhage is one of the most dangerous conditions for women's health. This pathological condition occurs during pregnancy or in the postpartum period and, in many cases, puts the woman's life at risk. Among the complex mechanisms of this condition, the pathologomorphological changes of the placenta (placenta) are of particular importance. Structural and functional disturbances that occur in the placenta increase the risk of increased hemorrhage anddeath inthe female body. 98,7:ROTCAFTCAPMI.SECNEICS LACIDEM,5202, yraurbeF,5emuloV gro.srehsilbupcimedaca.www Studies show that in females that die due to uterine hemorrhage, changes are mainly observed in the placenta - blockage of blood vessels, thrombosis, necrosis and fibrinoid degeneration. Such pathologies are accompanied by deformation of the structure of the placenta, as well as a violation of its circulatory function. These changes can lead to fetal hypoxia, intrauterine death, orother severe pregnancy complications. Also noted are the processes of blood transfusion and tissue death in some parts of the placenta. These conditions lead to an increase in the duration and volume of bleeding, which makes it difficult to control the process. Vascular necrosis and atrophy of the villos are associated withdangerous consequences, especially inthe last trimesterofpregnancy. Early detection and control of such complex mechanisms of placental pathology is important in order to reduce female mortality during pregnancy. Therefore, it is necessary to regularly monitor the structure of the satellite and develop practical measures to prevent pathological processes. The present article is devoted to elucidating this complex problem, which aims to investigate indepththe pathology of theplacenta and thereby improve thehealth of pregnant women. Research methods. For the study, the placenta of 20 women who died due to uterine bleeding were analyzed. Satellite specimens were subjected to microscopic and macroscopic examination in the pathology laboratory. The main attention was focused on changes in the circulatory system, necrosis of the placental tissues, fibrinoid degeneration and other pathological processes. In this study, the methods of macroscopic examination, microscopic examination, immunohistochemical analysis, clinical data analysis, statistical analysis were used to identify changes in theplacenta ofwomen who died dueto uterine hemorrhage. Changes in the overall structure, size, shape and surface of the placenta were examined for detection with eyes and with the use of special instruments. Blood clots in the placental tissues,necrosis and other external pathological signs were noted. The tissue of the placenta was analyzed under a microscope using special histological methods. This method made it possible to detect vascular involvement, fibrinoid degeneration, villosis necrosis and other microscopic changes. For tissue staining, staining methodssuch as hematoxylin-eosin and Van-Gizon were used. Immunohistochemical markers were used to determine the degree of disturbance of blood vessels and cell activity in the placenta. This method helped to study in depth the changes in thecirculatory system oftheplacenta. Medical records of deceased women (medical history, laboratory and instrumental examination results) were studied. This method made it possible to identify the causes of hemorrhages and itseffect onthe pathology of theplacenta. Results of the study. The results were processed using statistical methods to assess the frequency of occurrence ofchanges and theirrelationship with bleeding. 98,7:ROTCAFTCAPMI.SECNEICS LACIDEM,5202, yraurbeF,5emuloV gro.srehsilbupcimedaca.www The data obtai