Study of sensitivity to systemic antibiotics s. Epidermidis and s. Aureus in patients with moderate and severe acne

Аннотация

The sensitivity of S. epidermidis and S. aureus isolated from patients with moderate and severe acne to minocycline, doxylan, tetracycline and erythromycin in the treatment of this pathology. The antibiotic sensitivity of isolated strains was determined by the disco diffusion method on Mueller-Hinton agar in accordance with the guidelines. The data obtained make it possible to recommend the drugs minocycline and doxylan for clinical use in the treatment of patients with moderate to severe acne in dermatological practice. Keywords: Acne, staphylococci, antibiotic resistance, antibacterial drugs. content in food products, etc. Only with a full course (!) Introduction: Antibiotics (AB) are used to treat of antibiotic therapy (ABT) does the bacteria die. If the bacterial and fungal infections (they do not affect course is interrupted, then during this time the bacteria viruses). AB successfully fight severe bacterial only weaken under the influence of AB, but do not die. infections that the human immune system cannot cope Also, incomplete courses of ABT are one of the reasons with on its own. They can kill bacteria or stop their for the development of bacterial resistance to AB. reproduction, allowing natural defense mechanisms to eliminate them. Antibiotic resistance (AR) is the Microbiome resistance (MR) to antimicrobials and resistance of bacteria to an antibiotic, i.e. the antibiotic antibiotics is recognized as a serious public health becomes familiar, habitual for the bacteria and problem worldwide [4]. When prescribing antibiotics, it ineffective for treatment. The causes of ABR can be - is necessary to consider the entire spectrum of their widespread use of antibacterial drugs (ABP), taking AB antimicrobial action, since P. acnes is not the only without indications, violation of AB intake regimens, AB microorganism responsible for the development of International Journal of Medical Sciences And Clinical Research 73 https://theusajournals.com/index.php/ijmscr International Journal of Medical Sciences And Clinical Research (ISSN: 2771-2265) inflammatory reactions in patients with acne. The main of the study was to evaluate the sensitivity of S. representatives of the resident microbiome in acne epidermidis and S. aureus isolated from patients with patients are Cutibacterium acnes (C. acnes) and moderate to severe acne to systemic antibiotics, Staphylococcus epidermidis (S. epidermidis), while the namely minocycline, doxylane (doxycycline), transient microbiome mainly consists of tetracycline (tetracycline group) and erythromycin Staphylococcus aureus (S. aureus) [1]. Based on the (macrolide group) in the treatment of this pathology. results of scientific and clinical studies conducted in METHODS recent years, it has been suggested that the The study material consisted of clinical samples taken pathophysiology of inflammatory forms of acne is not from patients with moderate (n= 42) and severe (n= 29) so much involved in known pathogens, but rather in the acne. A total of 71 people were examined for this imbalance of microorganisms living on the skin or purpose. Staphylococcal microflora was cultured from "dysbacteriosis" of the skin microflora [2]. facial skin using the print method and identified using Systemic antibiotics are used to treat moderate to the standard scheme [3]. The culture was performed on severe acne: minocycline, doxycycline, tetracycline and blood and yolk-salt agar (YSA). Antibiotic sensitivity of erythromycin. All types of coagulase-negative and isolated strains was determined using the disk diffusion Staphylococcus aureus are generally characterized by a method on Mueller-Hinton agar in accordance with the high frequency of isolation of resistant forms, a high guidelines [9]. Statistical data processing was level and a wide spectrum of acquired resistance to performed using a program embedded in Microsoft antibiotics. At the same time, the indicators of acquired Excel. resistance in individual types of staphylococci, in RESULTS AND DISCUSSION relation to different drugs and depending on the habitat (hospital, community environment, surgical The assessment of the sensitivity of the isolated strains hospitals) have significant differences, which should be of S. epidermidis and S. aureus to various antibiotics is taken into account in the tactics of treatment and presented in diagrams 1 and 2. prevention of diseases caused by them [5,6,8]. The aim Diagram 1 Sensitivity of S. epidermidis strains (n=23) to antimicrobial drugs isolated from patients with moderate to severe acne, tetracycline and macrolide antibiotics (in %). 26% 78% 61% 74% Миноциклин Доксилан Тетрациклин Эритромицин Diagram 2 Sensitivity of S. aureus strains (n=19) to antimicrobial drugs isolated from patients with moderate and severe acne, tetracycline and macrolide antibiotics (in %). International Journal of Medical Sciences And Clinical Research 74 https://theusajournals.com/index.php/ijmscr International Journal of M