Development of composition and technology of capsule drug form extracted based on "cobalt-30 neo" substance

Аннотация

The fractional composition, dispersibility, bulk density, and residual moisture of the γ-cyclodextrin derivative of Cobalt-30, the "Cobalt-30 neo" substance, were determined according to the applicable regulations. In developing the composition and technology of the capsules, the type and number of excipients were selected, taking into account the technological properties of the mass. The composition and technology of the "Cobalt-30" capsule were developed, and all these aspects were thoroughly studied in the article. Keywords: "Cobalt-30 Neo", dispersibility, bulk density, residual moisture, capsule drug form, excipients. HP-γ-CD. Introduction: One of the urgent and important issues of the modern pharmaceutical industry is to increase Relevance of the topic. Currently, among ready-to-use the solubility of drugs, control the concentration and drugs produced on an industrial scale, capsule drugs rate of release of active substances from the drug form. take the leading place. The capsule form of the drug is In order to solve this problem, various excipients are precisely dosed, has a rapid effect on the body and is used, as well as methods of incorporating drugs into highly bio-efficient, and has the ability to prolong and nano-sized materials are being used. In particular, the control the action of the active substance. cyclodextrin (CD) complex is increasingly attracting the When choosing the composition and technology of attention of scientists among many nanoscale agents. certain capsules, it is of great practical importance to Nowadays, cyclodextrin molecules are widely used by study the technological properties of the mass to be scientists to create various drug forms. The use of placed inside the capsule. Also, the technological cyclodextrin and its derivatives makes it possible to properties of the substance "Cobalt-30 Neo" have a increase the stability of substances, reduce side effects, significant impact on the choice of the type of drug, the active substances to easily pass through biological composition of excipients and the technology of barriers, and to achieve high effectiveness in small obtaining the drug. If the technological features of the doses. Today, a derivative of cyclodextrins with high substance, such as fractional composition, solubility and drug solubilizing activity - hydroxypropyl- dispersibility, bulk density, and residual moisture, are γ-cyclodextrin (HP-γ-CD) is also widely used. In this within the standard limits, the capsule fills evenly with regard, Cobalt-30, a substance used in leukopoiesis and the substance, ensuring a consistent average capsule hepatitis diseases, was synthesized as a supramolecular weight. Moreover, the quantitative analysis meets the complex compound with HP-γ-CD. required standards, ensuring the stability of the The purpose of the work: to develop a capsule drug capsule. form with optimal composition and scientific basis Experience part. The experiments were based on based on the complex combination of Cobalt-30 with determining the physicochemical features and American Journal Of Biomedical Science & Pharmaceutical Innovation 20 https://theusajournals.com/index.php/ajbspi American Journal of Applied Science and Technology (ISSN: 2771-2745) technological properties of the mass to be indicators that directly affect the technological encapsulated. The structural - mechanical properties of properties of the mass to be encapsulated. the substance, specifically, the shape and size of the Physicochemical properties of particles were particles, were determined according to the methods determined using an ADF U300P microscope with a given in the section 2.9.37 "Optical microscopy" of the magnification of 10 to 600 times (Figure 1). State Pharmacopoeia of the Republic of Uzbekistan. The size and shape of the particles are one of the main Figure 1. Magnified images of the substance "Cobalt-30 Neo" under an electron microscope Looking at Figure 1, it can be seen that the substance different diameters and then sieved. For this purpose, "Cobalt-30 Neo" is a polydisperse powder composed of 100 g of mass was placed on the uppermost sieve and various particles, and it is mainly composed of plate- a mechanical oscillatory motion was created for 5 shaped irregular particles of similar length and width. minutes. Then the sieves were opened, the masses on At the next stage of the research, the technological the sieve were weighed individually with an accuracy of properties of the substance "Cobalt-30 Neo" were 0.01g, and the obtained results were written in the studied, and the results of the fractional composition form of Table 1. The ones that remained on the sieve analysis are presented in Table 1. The fractional were marked with (+), and the ones that passed composition of the substance was determined through the sieve were marked with (-). Fractional according to the method presented in the scientific composition was expressed in µm, %. literature. To determine th