PATHOGENETIC SUBSTANTIATION AND OPTIMIZATION OF TREATMENT OF INFLAMMATORY PERIODONTAL DISEASES IN PATIENTS WITH GASTROINTESTINAL TRACT PATHOLOGY

Аннотация

The article analyzes the pathogenetic mechanisms linking inflammatory periodontal diseases and gastrointestinal tract disorders. The influence of microbiome imbalance, cytokine dysregulation, and systemic inflammation on periodontal tissues is discussed. Particular attention is given to the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in this patient category. The rationale for using local NSAID formulations (gels, applications, mouth rinses) as a promising approach to reducing inflammation and minimizing gastrointestinal side effects is provided. The prospects of combination therapy involving gastroprotectors, probiotics, and herbal components are highlighted. Keywords: inflammatory periodontal diseases, gastrointestinal tract, nonsteroidal anti-inflammatory drugs, local application, NSAIDs, gastropathy, combination therapy.