CLINICAL AND IMMUNOLOGICAL ASPECTS OF PROGNOSIS AND PREVENTION OF GENERALIZATION OF INFECTION IN PATIENTS WITH CHRONIC WOUNDS

Аннотация

The article deals with clinical and immunological aspects of prognosis and prevention of generalization of infection in patients with chronic non-healing wounds. Risk factors for infectious complications, mechanisms of inflammation, and features of the immune response in the context of long-term wound healing are discussed. Methods for diagnosing and monitoring the state of the immune system, as well as the principles of treatment and prevention of infection, including the use of antibacterial and immunomodulatory drugs, are described. Recommendations for optimizing approaches in the treatment and prevention of generalization of infection are proposed. Key words: chronic wounds, generalization of infection, immune response, infection prevention, antibacterial therapy, inflammation, immunomodulation, clinical aspects. Relevance Chronic non-healing wounds are a serious medical problem that requires a comprehensive approach to the treatment and prevention of infectious complications. Existing treatments often do not lead to complete healing, which increases the risk of generalization of infection, the development of sepsis and other serious diseases. An important role in preventing these complications is played by the patient's immunological status, which can significantly affect the rate of healing and the risk of infectious complications. The relevance of this work is determined by the need to develop new effective methods of diagnosis and therapy to prevent generalization of infection in such patients. The development of techniques aimed at strengthening the immune response and reducing the inflammatory process is crucial for improving the prognosis and quality of life of patients with chronic wounds. Objective The aim of the study is to assess the clinical and immunological factors affecting the generalization of infection in patients with chronic non-healing wounds, as well as to develop effective methods for the prevention and treatment of infectious complications. 28 DEVELOPMENT AND INNOVATIONS IN SCIENCE International scientific-online conference