Currency and diagnostic criteria of rheumatoid arthritis in patients of senior age groups

Аннотация

This article presents the results of the study of CITATION the peculiarities of the course and diagnosis of rheumatoid arthritis (RA) in elderly people. In our work COPYRIGHT we studied 56 RA patients. Of these, 25 (44.6%) of the © 2025 Original content from this work may be used under the terms patients first fell ill in old age, 16 (28.5%) of patients of the creative commons attributes 4.0 License. became ill for more than 15 years and 15 (26.7%) of patients younger than 45 years made up a control group. Keywords: Rheumatoid arthritis, elderly age. Introduction: According to various research groups, rheumatoid arthritis (RA) affects 0.5-2.5% of the adult population [3,6]. RA can occur in childhood (juvenile RA), but most often the age of onset is the age of onset of the disease is 52±15 years. Among people under 35 years of age, the prevalence of RA is 0.38%, and in people over 55 years of age - 1.4%. Women are more likely to get sick than men - 2-3:1 [2]. A high incidence of RA is noted in first-degree relatives (3.5%), especially in females (5.1%). The last two decades have seen significant advances in the study of the pathophysiology and treatment of rheumatoid arthritis. The aphorism that was widely used in the 1960s-80s was: “We don't treat RA, we manage the patient with the disease" – today can be considered an anachronism [4]. Timely administration (i.e., at the early stages of the disease, ideally in the first three months) of disease- modifying antirheumatic drugs (DMARDs) in adequate doses independently, and if necessary, in various combinations, allows in many cases to successfully control the activity of the disease, prevent or slow down the development of erosive processes [5]. A major achievement was the creation and introduction into clinical practice of RA treatment of so-called biological The American Journal of Medical Sciences and Pharmaceutical Research 86 https://www.theamericanjournals.com/index.php/tajmspr The American Journal of Medical Sciences and Pharmaceutical Research agents of medical preparations obtained by genetic disability. In the prevention of rheumatological engineering, the targets of which are key diseases, including rheumatoid arthritis in the elderly, it proinflammatory cytokines, their receptors and allows normalizing bone remodeling processes, immunocompetent cells. improving its strength characteristics, reducing the risk of fractures, and improving the quality of life. The results of a number of studies allow us to look with optimism at the possibilities of low doses of The social significance of RA is determined not only by glucocorticoids (GC) both in controlling the activity of its widespread prevalence, but above all by the fact that the disease and in slowing the progression of joint it quickly leads to disability of patients, with the ensuing lesions. In old age, according to some data, the onset consequences: a change in the quality of life and great of RA is often characterized by a low degree of activity material damage caused to both the patient and the of the inflammatory process, which, when assessed patient himself. retrospectively, is classified as a “chronic” course of both the patient and society [7]. the disease.” Objective of the research work to study of diagnostic In such cases, the signs of articular syndrome develop criteria of RA in elderly people. gradually over several months [8]. Extra-articular METHODS manifestations of the disease are observed in no more than 20% of cases. In approximately 2/3 of elderly The observation included 56 patients who came to the patients, RA begins with symmetrical oligoarthritis, in Akfa University Clinic “Akfa medline ”, for 2018-2020, of 1/3 with symmetrical polyarthritis. Damage to large which 25 (44.6%) patients who first became ill at an joints at the onset of the disease is observed in 30% of elderly age, 16 (28.5%) patients with a disease history of cases. According to other authors, the onset of more than 15 years and 15 (26.7%) patients were under rheumatoid arthritis in elderly individuals is more 45 years old, who constituted the control group. acute, with virtually no prodrome. The diagnosis of RA was carried out according to the There is a predominant lesion of large joints rather criteria of experts of the American College of than small joints of the hands and feet. There is a Rheumatology and the European League Against leveling in the sex ratio: the ratio of men to women is Rheumatism (ACR/EULAR RA) 2010 and taking into 1:1, while at a younger age, women predominate. account the additions made by the staff Institute of Identification of new inflammation markers, the use of Rheumatology of the Russian Academy of Medical ultrasound and magnetic resonance imaging (MRI) Sciences. Of the total number of RA patients who first have significantly improved the diagnosis of RA and developed the disease in old age, there were 14 men dynamic monitoring of the effectiveness of therapy (21.2%) and 52 wo