Состояние активности ферментов микросомального окисления и нитрооксидергической системы в микросомах гепатоцитов при действии индукторов no-системы у животных, перенесших острую гипоксию печени

Аннотация

In researches on white not purebred rats males the mass of a body 180-240g. it is established that in groups after 1, 3 and 10 days of ischemia of a liver and daily intravenous administration of effective doses inductors of nitrooksidazy system (NOS): nitroprusid Na (0,03mg/kg), L-arginin (50mg/kg), Gepa-Mertz (50mg/kg) and molsido- min (50mg/kg) have not unidirectional impact allocated of gepatocite in microsomes, on activity' of enzymes of monooxygenase system (MOS); parameters NO systems characterizing level - the content of oxide of nitrogen, activity of endotelial NOS, indutsibel NOS and concentration ONOT. The direct inductor NOS - nitroprusid Na oppresses activity MOS, and indirect Larginin, Gepa-Mertz and molsidomin render positive corrective effect, up to restoration of separate parameters of MOS and NOS to control values.