SOME ISSUES ON THE USE OF THE MEDICINAL PRODUCT DECACAN IN MEDICINE AND THE MECHANISM OF ACTION

Аннотация

В данной статье рассматривается применение препарата Декасан в медицине и механизм его действия. Декасан накапливается в цитоплазматической мембране (СПМ) микробной клетки и связывается с фосфатидными группами мембранных липидов, нарушая СПМ микроорганизмов и оказывая противомикробное и противогрибковое действие. Ключевые слова: бактерицидный эффект, резистентный, применение, микротрахеостомия, дифтерия. Introduction. Decacan (or decamethoxin) is an antiseptic and antimicrobial agent, usually used to treat upper respiratory tract infections such as rhinitis, pharyngitis, tracheitis and other inflammatory processes in the nasal and laryngeal areas. Decasan has a pronounced bactericidal effect on staphylococci, streptococci, diphtheria and pertussis bacillus and encapsulated bacteria, fungicidal effect on 335 “JOURNAL OF SCIENCE-INNOVATIVE RESEARCH IN UZBEKISTAN” JURNALI VOLUME 3, ISSUE 01, 2025. YANUARY ResearchBib Impact Factor: 9.654/2024 ISSN 2992-8869 yeasts, yeast-like fungi, pathogens of epidermophytosis, trichophytosis, microsporia, erythrasma, some types of mold fungi (aspergillus, penicillin), protisticidal effect on Trichomonas, Giardia, virucidal effect on viruses. Decacan (active ingredient - decamethoxin) according to the ATC classification belongs to the group of antiseptic and disinfectant drugs. It has a wide range of antimicrobial, antifungal and antiviral action due to the ability to interact with the phosphate groups of lipids of the cytoplasmic membrane of microorganisms and thus disrupt its permeability and lead to cell destruction. Decamethoxin has been used in clinical practice since the 1970s and to this day with consistently high efficiency, has a wide range of indications for use. Main part. An antimicrobial antifungal drug that concentrates on the cytoplasmic membrane (CPM) of a microbial cell and combines with phosphatide groups of membrane lipids, disrupting the permeability of the CPM of microorganisms. Decamethoxin has a pronounced bactericidal effect on staphylococci, streptococci, diphtheria and pseudomonas aeruginosa, capsular bacteria and a fungicidal effect on yeast, yeast-like fungi, causative agents of epidermophytosis, trichophytosis, microsporia, erythrasma, some types of mold fungi (aspergillus, penicillium), protisticidal effect on trichomonads, lamblia, and a virucidal effect. It is highly active against microorganisms resistant to antibiotics. The formation of forms resistant to decamethoxin with prolonged use occurs slowly and does not exceed the effective concentrations of the drug. Bacteriostatic (fungistatic) concentrations are similar to its bactericidal (fungicidal), virucidal, protisticidal concentrations. During treatment with the drug, the sensitivity of antibiotic-resistant microorganisms to antibiotics increases. The drug is practically not absorbed by mucous membranes, intact skin and wound surfaces. It is highly active against microorganisms resistant to antibiotics. With prolonged use, the formation of Decasan-resistant forms of microorganisms occurs slowly and does not increase the effective concentrations of the drug. Bacteriostatic (fungistatic) concentrations are similar to its bactericidal (fungicidal), virucidal, and protisticidal concentrations. During treatment with the drug, the sensitivity of antibiotic-resistant microorganisms to antibiotics increases. 1 ml of solution contains 0.2 mg of Decasan, excipients: sodium chloride, water for injection, is a clear, colorless solution. It is an antiseptic and disinfectant ATX code: D08A, belongs to the group of structural agents 336 “JOURNAL OF SCIENCE-INNOVATIVE RESEARCH IN UZBEKISTAN” JURNALI VOLUME 3, ISSUE 01, 2025. YANUARY ResearchBib Impact Factor: 9.654/2024 ISSN 2992-8869 Treatment of pustular bacterial and fungal skin diseases, microbial eczema, purulent-inflammatory lesions of soft tissues (abscess, carbuncle, phlegmon, furuncle, infected wounds, panaritium); dental diseases (stomatitis, ulcerative- necrotic gingivitis, dystrophic-inflammatory form of periodontosis of I-II degree in the acute phase). Indicated for lung abscess, bronchiectasis, cystic hypoplasia of the lungs complicated by suppuration, chronic bronchitis in the acute phase, chronic tonsillitis, sore throat, carriage of staphylococci and diphtheria bacilli, ulcerative colitis, paraproctitis. In surgical infectious and inflammatory diseases of the abdominal cavity (peritonitis of various etiologies) and in pulmonology, Decacan is used to wash the abdominal and pleural cavity. In urology, the drug is used for urethritis (for instillation into the urethra), balanaposthitis (for baths), prostatitis (for microclysters), cystitis (for instillation into the bladder), for irrigation of the bladder in the postoperative period. In gynecological practice, Decacan is used to treat candidiasis of the vaginal mucosa, inflammatory diseases of the external genitalia of microbial etiology, prenatal sanitation of the birth canal, and treatmen