DEVELOPMENT AND VALIDATION OF AN INNOVATIVE ANALYTICAL METHOD FOR CEFOXITIN IN PHARMACEUTICAL FORMS

Аннотация

The development and validation of an innovative analytical method for the quantification of cefoxitin, a new β-lactam antibiotic, are crucial for ensuring its quality, safety, and efficacy in pharmaceutical formulations. This study presents the creation of a novel analytical method that combines [mention techniques, e.g., high-performance liquid chromatography (HPLC), UV-Vis spectrophotometry, or any other specific method used] for the precise determination of cefoxitin in both bulk and dosage forms. The method was optimized for sensitivity, specificity, and reproducibility, and it was rigorously validated according to ICH guidelines for parameters such as linearity, accuracy, precision, specificity, limit of detection (LOD), limit of quantification (LOQ), and robustness. The method demonstrated excellent performance with a high degree of accuracy and precision, ensuring reliable quantification of cefoxitin in various pharmaceutical forms, including injectable solutions and tablets. The proposed method offers a fast, cost-effective, and reliable alternative for routine quality control in the pharmaceutical industry, ensuring the proper dosing of cefoxitin in clinical settings. KEYWORDS Cefoxitin, β-Lactam Antibiotics, Analytical Method Development, Method Validation, Pharmaceutical Forms, High- Performance Liquid Chromatography (HPLC), UV-Vis Spectrophotometry, Accuracy.