FOLATE METABOLISM AND ITS ASSOCIATION WITH CERVICAL DISEASE

Аннотация

Cervical cancer is one of the few cancers that can be prevented. When it is diagnosed at an early stage, the disease is more amenable to effective treatment, which increases overall and relapse-free survival, improves the quality of life of patients, and reduces the cost of treatment. According to international guidelines, Human Papillomavirus (HPV) DNA tests represent a valid alternative to Pap Test for primary cervical cancer screening, provided that they guarantee balanced clinical sensitivity and specifcity for cervical intraepithelial neoplasia grade 2 or more (CIN2+) lesions. The study aimed to assess whether HPV Selfy (Ulisse BioMed – Trieste, Italy), a full-genotyping HPV DNA test that detects and diferentiates 14 high-risk HPV (HR-HPV) types, meets the criteria for primary cervical cancer screening described in the international guidelines, on clinician-collected as well as on self-collected samples.