Клинико– иммунологическое обоснование при протезировании акрилатами больных с аллергическим фоном

Аннотация

Subject of research: 117 patients, of them 28 were without allergy; 77 ones with allergic background and without allergy to basic plastic, 12 patients with allergy to acrylic plastic. Purpose of work: To undertake a clinical and immunologic study and on its basis to develop approaches for predicting allergic effects of basic plastics on oral mucosa in patients with allergic background. Methods of research: clinical, stomatoscopical, microbiological, immunologic and cytochemical. The results obtained and their novelty: It is demonstrated that in patients with allergic background (AB) the frequency of development of allergic response (AR) to plastics of a dental prosthesis (PDP) has made 13.48%. AR to PDP in the oral mucosa (OM) manifests itself in the form of hyperemia, edema, presence of teeth prints, disturbance in epithelium transparence in the fonn of opacification with elements of keratosis, various coatings, catarrhal events, hyperemia of glands and decubital stomatites. On the background of development of AR to PDP, enhancement of local immunity of OM, augmentation of T-LP, IRI rise, aggravation B-lymphopenia, rising in IL-4, IgE and IgG, a high NP activity in NBT-test were noted. The rise in NBT-test rates by over 15% at in vitro monomer affect prior to prosthetic repair was associated with development of allergic response following prosthetic repair. Practical value: Introduction of prediction of risk of development of the allergic response based on NBT-test rates into orthopedic stomatology will enable to optimize selection of basic materials for patients with allergic background, to lower economic and moral damage caused by it. Degree of embed and economic effectivity: The results of the research are used in medical practice of an orthopedic stomatologic out-patient department of the Third Clinic of the Tashkent Medical Academy and in the educational process oat the faculty of orthopedic stomatology and orthodontology of the Tashkent Medical Academy. Field of application: stomatology.