Реакции микрососудов пиальной оболочки мозга и реологические свойства крови в остром периоде субарахноидального кровоизлияния (экспериментальное исследование)

Аннотация

Objects of research: pancreas gland, liver, small intestine, blood of experimental rats with acute pancreatitis. Purpose of research: studying dynamic of changes in essential trace elements content in different tissues, interplays between their contents and structural metabolic disturbances in pancreas gland, liver and small intestine for acute experimental pancreatitis. Methods of research: neutron activation analysis, biomicroscopy, biochemical methods of studying enzymes’ activity, biophysical methods of studying rheologic features of blood, light microscopy of tissues. Results obtained and their novelty: Development of acute pancreatitis was accompanied by reducing selenium content and, especially cobalt in blood plasma, liver and pancreas gland, increasing their content in small intestine in interstitial-edematous and parenchymatous (purulent-necrotic) period. Content of zinc, chromium and iron in small intestine and pancreas gland was decreasing, whereas they were wavy in blood serum and liver. There is a close correlation between selenium, zinc, chromium content and SOD, gluthathionc peroxidase activity in the mentioncd tissues. Level changes in the mentioned trace elements, microcirculation disturbances in the tissues studying and blood rheologic features, due to acute inflammation of glandular parenchyma on the one hand, and striking increasing its concentration on the other hand, and, therefore, aggression of protco- and hydrolytic enzymes of pancreas gland, determine uncontrolled LPO intensification. A close anatomic physiologic interrelation between pancreas gland and liver and small intestine causes development of structural changes in the mentioned organs for acute cryogen pancreatitis. Such pronounced hcmocirculation disorders as dilatation and blood formation in microvessels of exchange link revealed to be in earlier terms of experiments. These changes were rapidly enough transformed in extensive destructive and inflammatory changes of parenchymas of pancreas gland and liver. Desquamation areas in mucosal epithelium were revealed in small intestine in late terms of research. Practical value of research: Results obtained expose importance of essential trace elements for development of structural functional disorders in pancreas gland for its acute inflammation. Establishcmcnt of trace lemcnts’ homeostasis disturbances in digestive organs and their involvement in pathologic process evidence a necessity to wotk out measurements aimed at correction of trace elements’ disbalance. Inplcmcntation degree and economic effectiveness: Main statements of the thesis arc included into a course of lectures and practical lessons on the chairs of Normal & Pathologic Physiology of the 2nd TashMI. Field of application: Medicine