КОМПЛЕКСНЫЕ СОЕДИНЕНИЯ ПЕРЕХОДНЫХ МЕТАЛЛОВ С ПОЛИФУНКЦИОНАЛЬНЫМИ 2-ЗАМЕЩЕННЫМИ БЕНЗИМИДАЗОЛАМИ

Аннотация

Subject of inquiry: polyfunctional 2-substituted benzimidazoles, transition metals - Co, Ni, Cu, Zn, Cd(II), V(IV,V). Aim of inquiry: synthesis, study, establishment the complex formation laws of single and mixedligand coordination compounds of transitional metals with the polyfunctional 2-substituted benzimidazoles and determination of biological activity a number of synthesized complex compounds Method of inquiry: X-ray structural, elemental, thermal analysis, IR-and PMR-spectroscopy, quantum-chemical calculations. The results achieved and their novelty: 32 new complexes of chlorides, nitrates, acetates and acetylacetonates of Co, Ni, Cu, Zn, Cd(II), V(IV,V) on the base of benzimidazole derivatives were synthesized. For the first time the crystal structures of 10 complex and ligands were calculated. Composition, structure, physical-chemical properties were determined and new complexes possessing antihypoglycemic activity were obtained. Practical value: developed conditions and methods of the 2-substituted benzimidazoles derivatives and its metal complexes on their base can be base for creation of practical recommendations on aimed synthesis of related coordinated compounds and also for forecast of the heterocyclic ligands and transitional metal complexes properties and structure. The determinated antihypoglycemic activity of the synthesized new vanadium complexes has indicated on the possibility of their application at creation of medicinal preparations for diabetes treatments. Degree of application and economical efficiency: obtained experimental data were realized in education processes on department of inorganic and analytical chemistry of NUU and department of analytical chemistry and technology of noble metals of TCTI. Sphere of usage: coordination chemistry, analytical chemistry, organic chemistry, medicine.