Особенности нарушения рецепторных свойств мембран клеток мозга при экспериментальной дисфункции щитовидной железы

Аннотация

Subject of the inquiry: brain of 168 mongrel rats Aim of the inquiry: to define peculiarities and mechanisms of receptor properties disorder of brain cell membrane in experimental pathology of thyroid glands. Methods of inquiry: biochemical, biophysical, morphological, statistical. The results achieved and their novelty: for the first time, it has been shown that hyperthyroidism results in reduction, but hypothyroidism - in density increase of GAOA - benzodiazepine-binding sites on GAOA receptors as well as CPP-binding sites on glutamate receptors of NMDA-type in synaptosomes. At the same time, the density of kainite-binding sites on glutamate receptors of kainite-type in synaptosomes from different areas in hypothyroidism is decreased but in hyperthyroidism is increased.G-6-PDG and K+, Na+- ATPase activity in hypothyroidism has been decreased as far as pathology progressing, in hyperthyroidism has been increased. In rats with hypo- and hyperthyroidism there revealed disbalance in POL/AOD system which promotes the development of hyperperoxidation of lipids more marked in thyroid gland hypofunction. Hypo-and hyperthyroidism in rats result in the development of discirculatory changes of different peculiarities in all areas of brain. Histochemically, in hyperthyroidism reduction of content nerve cells of tigroid substance in cytoplasm are noted, but in hypothyroidism hyperchromia and hypertrophy are detected. Practical value: the work mainly has fundamental character and finds out the mechanism of receptor properties disorder of brain cells conditioning peculiarities of the development of neurological manifestations in thyroid gland pathologies, their interconnection with structural and functional membrane disorders. Degree of embed and economic effectivity: study results have been embedded into practice of CRL TMA experimental department, introduced in academic process - in delivering of lectures and practical lessons in Biochemistry. Field of application: fundamental medicine and biology.