Исследование ассоциации полиморфизма гена урокиназы с развитием уролитиаза в Узбекскистане

Аннотация

The obtained results in this study suggest that genetic variants of the gene polymorphism to be marked as urokinase 3'-UTR T / C contribute to a determination of the development of the ICD sposobstvuyuschix disorders. In particular, the residents of the Republic of Uzbekistan genetic markers of predisposition to ICD genotypes T / T and P / T. With Policy markers can be carried out identifying risk groups of the ICD. The advantage of molecular-genetic method for predicting the ICD using genetic markers is that a predisposition to the disease may be established in the absence of any clinical or biochemical manifestations, t. E. At a very early preclinical stage of pathology, which will contribute to a focused preventive measures and improve the quality of life of these patients. Found an association between the presence of genotype T / T and C / T gene of urokinase and urolithiasis, consider it appropriate to include the definition of a gene of urokinase in a comprehensive program of prevention ICD in Uzbekistan