LIVER ENZYME ALTERATIONS ASSOCIATED WITH PLASMODIUM VIVAX AND FALCIPARUM MALARIA

Аннотация

Malaria, caused by Plasmodium species, poses significant health challenges worldwide, particularly in endemic regions. This study investigates the alterations in liver enzyme levels associated with Plasmodium vivax and Plasmodium falciparum infections. We conducted a comparative analysis of liver function tests (LFTs) among confirmed malaria patients infected with either species, alongside a control group of healthy individuals. Enzyme levels, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and bilirubin, were measured and analyzed. Our findings reveal a significant elevation in liver enzyme levels in patients infected with both P. vivax and P. falciparum compared to controls, with P. falciparum infections showing more pronounced derangements. The alterations in enzyme levels correlate with clinical severity and indicate potential hepatic involvement in malaria pathophysiology. These results underscore the importance of monitoring liver function in malaria patients and may contribute to developing targeted therapeutic strategies to mitigate hepatic complications. Further studies are warranted to elucidate the underlying mechanisms of liver enzyme derangement in malaria infections. KEYWORDS Liver enzymes, Plasmodium vivax, Plasmodium falciparum, malaria, liver function tests, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, hepatic involvement, malaria complications. Volume 04 Issue 10-2024 1 American Journal Of Biomedical Science & Pharmaceutical Innovation (ISSN – 2771-2753) VOLUME 04 ISSUE 10 PAGES: 1-7 OCLC – 1121105677 Publisher: Oscar Publishing Services Servi