MAIN ECHOCARDIOGRAPHIC PARAMETERS IN PATIENTS WITH CHRONIC CEREBRAL ISCHEMIA DEPENDING ON THE PRESENCE OF CONCOMITANT CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Аннотация

INTRODUCTION According to the World Health Organization, artery (PA), which over time causes structural chronic obstructive pulmonary disease (COPD) changes in the right chambers of the heart and caused the death of 2.32 million people in 2019 [1]. right ventricular failure [1,2]. Chronic inflammation, progressive emphysema, The first key provision of chronic obstructive and pulmonary hyperinflation lead to an increase pulmonary disease (COPD) is a disease in the afterload on the right ventricle (RV) in characterized by significant extrapulmonary patients with COPD due to an increase in manifestations that can further aggravate the pulmonary vascular resistance and a moderate course of the disease in individual patients [4,5]. increase in systolic pressure in the pulmonary According to the results of a large study in patients https://www.theamericanjournals.com/index.php/tajmspr 21 THE USA JOURNALS THE AMERICAN JOURNAL OF MEDICAL SCIENCES AND PHARMACEUTICAL RESEARCH (ISSN – 2689-1026) VOLUME 06 ISSUE10 hospitalized for exacerbation of COPD, the 42.9% (p < 0.05). The groups were dominated by prevalence of comorbidity with arterial elderly people according to WHO, 2022. hypertension (AH) is 65.6% [4,5]. The diagnosis and stages of CIM were established Aim: To study the main echocardiographic according to the generally accepted criteria for the parameters in patients with chronic cerebral Republic after conducting thorough clinical, ischemia depending on the presence of neurological, neuropsychological and concomitant chronic obstructive pulmonary instrumental (duplex scanning, MRI of the brain) disease. studies (3). METHODS The diagnosis of COPD was made on the basis of complaints (shortness of breath, cough with Over a period of 3 years, patients were selected: 1) sputum), clinical picture of the disease, anamnestic patients with CCI stage II with concomitant COPD data (presence of risk factors), results of physical (main group - MG); 2) patients with CCI stage II and laboratory examination methods, without COPD (comparison group - CG). The instrumental data (measurements of airflow control group (CG) included 20 patients, 10 men limitation (spirometry) - the ratio of FEV1 / FVC < and 10 women, average age 63.1±6.4 years (Table 70%; post-bronchodilator value of FEV1 less than 1). 80% of the expected) in accordance with the The MG comprised 57 patients (47.5%) and the CG “Global strategy for the diagnosis, treatment and comprised 63 patients (52.5%). As can be seen prevention of chronic obstructive pulmonary from Table 1, the MG had a predominance of males disease” (National Heart, Lung, and Blood - 34 (59.6%) versus females - 23 (40.4%) (p < Institute; revision 2008) and the “Respiratory 0.05). In the CG, there was a predominance of Medicine Guidelines” (6). women - 36 (57.1%), the proportion of men was Table.1. Distribution of patients by groups, gender and age Groups gender Age, WHO, 2022 60 - 74 years 75 - 90 years total old old M abs 13 21 34 % 38,2% 61,8% 59,6% MG F abs 9 14 23 n=57 % 39,1% 60,9% 40,4% total abs 22 35 57 % 38,6% 61,4% 47,5% M abs 9 18 27 https://www.theamericanjournals.com/index.php/tajmspr 22 THE USA JOURNALS THE AMERICAN JOURNAL OF MEDICAL SCIENCES AND PHARMACEUTICAL RESEARCH (ISSN – 2689-1026) VOLUME 06 ISSUE10 % 33,3% 66,7% 42,9% CG F abs 12 24 36 n=63 % 33,3% 66,7% 57,1% total abs 21 42 63 % 33,3% 66,7% 52,5% M абс 22 39 61 % 36,1% 63,9% 50,8% Total F abs 21 38 59 n=120 % 35,6% 64,4% 49,2% total abs 43 77 120 % 35,8% 64,2% 100,0% Note: OG - main group; CG - comparison group; m - men; f - women; abs - absolute values; WHO - World Health Organization. All patients underwent a standard clinical and carried out using variation statistics methods neurological examination (analysis of patient using Microsoft Office Excel-2019 programs. complaints, life history and medical history,