Морфологические и морфометрические изменения внутримозговых сосудов у женщин фертильного возраста

Аннотация

Subjects of the inquiry: Cerebral vessels and tissue in 105 dead women of fertile age. Aim of the inquiry: To study morphological and morphometric changes in the walls of intracerebral vessels in stroke in women of fertile age on the basis of results obtained and to form the base of information for prognosis of pathomorphological changes in the intracerebral vessels in the women with stroke. Methods of investigation: Morphological (hematoxilin and cosin, by Van-Gison, Nissle), morphometric (coefficient p, method of the formation of database for cerebral stroke). The results achieved and their novelty: In the women of fertile age among the forms of cerebral stroke the enccphalomalacia occurred more often (59,7%) than hemorrhages (40,3%). The area of middle cerebral artery is more often damaged (56,2%). On the territory of the posterior cerebral artery the stroke occurred in 29,3% of cases, of the anterior cerebral artery in 14,5%. In the etiological structure of the cerebral stroke there has been noted hypertensive disease (35,4%), systemic vasculites (30,5%), atherosclerosis (20,7%), complicated pregnancy (13,4%). The program developed allows automation the process of prognosis of morphological changes of intracerebral vessels and to perform differential diagnosis by four nosological groups (atherosclerosis, hypertensive disease, systemic vasculites and complicated pregnancy) in stroke of women of fertile age. Practical value: The data obtained should be taking into account by clinicians during performance of therapeutic-diagnostic measurements as well as physicians-pathoanatomists for adequate assessment of the state of intracerebral vessels. The algorithm of the work of the expert system may be used for differential diagnosis of the etiological factors in cerebral stroke in the women of fertile age. Degree of embed and economic effectivity: The developed computed program for prognosis has been introduced into the Department of neurology of the Clinic of Tashkent medical Academy and department of emergency medical Care of Chinaz Central Hospital. Sphere of usage: Pathological anatomy, Neurology.