Нарушение функционально-метаболических параметров печени при апластической анемии и коррекции их сукциносолом

Аннотация

Subjects of research: 42 rabbit’s chinchilla species, 45 patients of aplastic anemia and 20 healthy men. Purpose of work: To detect the peculiarities of the disorders of functional-metabolic parameters of liver and the development of endotoximia in aplastic anemia and correction them with new disentoxic agent «succinosol». Methods of research: General-clinical, biochemical, haematological, instrumental, statistical. The results obtained and their novelty: The experimental and clinical investigation showed the involving in pathologic process of liver during aplastic anemia, appearing with structural-functional disorders, and misbalance in system of ПОЛ/АОЗ on systemic and local levels. This process inhibits biotransformation of xenobiotics and leads to endotoximia. It is important to use the succinosol in its treatment, which does not let to using sorbilact in patients with AA by its properties. Practical value: In general the work has fundamental character and discovers the pathogenic mechanisms of liver insufficiency developments in experiment and in clinic; it has proved the necessity of dynamic control of liver condition AA.Thc remarkable change of structural- functional parameters of liver dictates the necessity of hepatoprotectors’ using and disentoxic therapy, to decrease the degree of endogen intoxication. Succinosol is more effective than wide using sorbilact: more economic, does not cause side effects. Degree of embed and economic effectivity: The results of investigation arc applied in the department of RIH and ВТ of the HM RUz, in educational process for the training of clinical attending physician. Field of application: haematology .