Белковый обмен у детей больных витилиго, в зависимости от микробиоценоза кишечника и методы их коррекции»

Аннотация

Subjects of the inquiry: blood, faeces, salvia of 132 children suffered from vitiligo at the age from 1 to 16 years. Aim of the inquiry. To study protein metabolism, microbiocynosis of intestine and disintoxicational function of liver in children suffered from vitiligo, depending on clinical forms of disease and to improve present methods of therapy. Methods of inquiry: clinical, bacteriological, biochemical. The results ahieved and their novelty. For the first time in children with vitiligo aminoacid blood spectrum, depending on clinical forms of disease, was researched. At the same time with hypcr-aminoacidcmia changes of correlation between different aminoacids were revealed: reduce of phenylalanine/tyrosine, histidine/glutaminc acid and serine/glycine. Coefficients raise of asparagin acid/alanin, glutamine acid/prolin shows to expressed metabolism disorder of aminoacids, intensified formation of ammonia in tissues and reduce of hepatocytes functional activity. Lcucin/isolcucin coefficient is increased in 1,2 times that witnesses about disorder of protein synthesis. It was revealed that in all patients with vitiligo, not depending on intestine disbacteriosis, statistically reliable raise of above mentioned aminoacids and insignificant reduce of phenylalanine concentration, was marked. For the first time influences of blood aminoacid spectrum on activity and vitiligo process course were analysed, that gave possibility to approach purposefully to complex treatment, including therapeutic nutrition. Practical value. Practical Health Care was suggested the carried out scheme of treatment of children suffering from vitiligo with inclusion of therapeutic nutrition (Diet 4B), that will take to a raise of therapy efficiency. Degree of embed and economical efficacy: Taken results arc used in pedagogical and therapeutic process at the departments of TashPMI, at dcrmatovenerealogy department and in the work of skin venereal dispensaries 3,5,6,8 in Tashkent city, in dermatological department of Tash. CityDVD and Tash. Rcg.DVD. Sphere of usage: dcrmatovenerealogy, pediatric.