Синтез супрамолекулярных комплексов производных глицирризиновой кислоты и их биологическая активность»

Аннотация

Objects of research: 18b-H glycyrrhizin acid and its salts, В SA, PSA, ASA, salicylic acid and benzoic acids, benzyl alcohol, phenol, and their supramolecular complexes. Purpose of work: Creating a water-soluble, low-toxic of NSAIDs on the basis of supramolecular complexes of MASGA with ASA, with a wide therapeutic effect and non-ulccrogcnic action. Methods of research: Bioorganic, supramolecular chemistry, chromatographic, physical and chemical (viscosimctry) and physical (optical spectroscopy). The results obtained and their novelty: For the first time were obtained on the base of mono ammonium, monosodium, mono potassium derivatives of the glycyrrhizic acid with ASA, and supramolecular complexes of MASGA with PSA, BSA, SA, benzoic acid, benzyl alcohol and phenol at different ratios. Hydrodynamic properties of water solutions of the MASGA and some its supramolecular complexes were studied. During obtaining of supramolecular complexes of MASGA with ASA (GLAS) in watcr-alcohol solution it is observed partial hydrolysis of ASA until to the SA. Supramolecular complex of GLAS has high а-and y-intcrfcron activities, and its maximal titer during 12-48 hours reached to 2000-8000 units. It is shown that GLAS has anti-inflammatory activity and has not ulcerogenic action. Practical value Created new preparate on the base of local row material could be highly effective medicinal drug. The degree of implementation and economic effectivity: According to the developed experimental production regulations a 1.0 kg of GLAS substance is obtained. Pilot industrial regulations for medicinal forms of GLAS drugs arc developed (0.05 g tablets № 10, 20, and 0.5% 10-20 ml nasal drops). Normative and technical documents arc transferred to the Pharmaceutical Committee of the Ministry of Health of the Republic of Uzbekistan. Field of applications: bioorganic chemistry, pharmaceutics and medicine.