СОСТОЯНИЕ ФУНКЦИИ ЭНДОТЕЛИЯ ПРИ РАЗЛИЧНЫХ ПАТОГЕНЕТИЧЕСКИХ ПОДТИПАХ ИШЕМИЧЕСКОГО ИНСУЛЬТА И ДИФФЕРЕНЦИРОВАННЫЕ ПОДХОДЫ К ЛЕЧЕНИЮ

Аннотация

Subjects of research: 80 patients with ischemic stroke and 20 with chronic investigated cerebral ischemia. Purpose of work: Assessment of endothelial function and vessel-platelets hemostasis in patients with ischemic stroke, depending on its pathogenetic heterogeneity with the subsequent development of a differentiated approach to treatment. Methods of research: clinical and neurological examination, color duplex scanning of the main arteries of the head (CDS MAG), multispiral computed tomography (MSCT), biochemical methods: measured levels of NO, the activity of eNOS and vWF, ADP-induced platelet aggregation The results obtained and their novelty: The relationship between indicators of the endothelial function with parameters in the platelet-vascular hemostasis in patients with heterogeneous AI with assessing the effects of the drug Tiotsetam. Found the degree of conjugation of endothelial dysfunction with the severity of the clinical course of disease. Practical value: Based on clinical studies and assessment of endothelial function algorithm therapy in patients with differentiated Tiotsetam inclusion of the drug, depending on the pathogenetic heterogeneity of AI, which may provide a new direction in the pharmacotherapy of underlying disease. Degree of embed and economic effectivity: the results have been implemented in medical and diagnostic practice offices therapeutic resuscitation of Bukhara branch of the National Research Center of Emergency Medicine, Department of Neurology 4 CCH them. I. Ergashev Tashkent. Field of application: neurology, intensive care, resuscitation, angio- and cardioneurology.