Механизмы формирования интеграции иммунной и пищеварительно-всасывательной функций тонкой кишки

Аннотация

Subject of the inquiry: white pcdigrceless (n=187) sterile rats (n=3), associated with lactobacteriums (n=9), usual gut organisms (n=9). Aim of the inquiry: study of the mucous tunic immune system (MTIS) of small bowel and mechanisms of its integration with digestion and absorption at hemostasis regulation. Methods of inquiry: morphological, immunological, biochemical, autoradiographic, statistic. The results achieved and their novelty: For the first time in the experiment in postnatal ontogenesis has been defined correlated formation of afferent links of MTIS and functional system of digestion and absorption of the small bowel for homostasis regulation, maintenance of tense immune potential during breast feeding, artificial and definitive feeding. Absorption made by erythrocyte of receptor mediated cndocytosis is typical for breast feeding and is slightly expressed in norm after passing to the definitive feeding. The model of association of sterile rats by lactobacteriums and normal intestinal flora has shown their different morpho- and immunogenity. Different proliferative activity of lymphoid cells of aggregate gland structural functional zones has been revealed autoradiographically by the index of marked nucleus as well as preferential migration of В-blasts to them from the blood, interaction of T and B-blasts with antigcnconnccting and antigenpresenting cells in cupola zone before migration into the lymph flow. Practical value: Mechanisms of integration of immune and digestive absorbent functional systems of the small bowel could be used at prevention and treatment of atopic, gastrocntcrologic diseases of children of the optimal scientifically based formation of the organism functional systems. Various grades of immunogenity of intestinal microorganisms is recommended to be used for purposeful prevention of disbacteriosis, food allergy. Discovery of the mechanisms of digestion and absorption and regulation of homostasis would allow to ground scientifically development of adapted feeding formulas. Degree of embed and economic effectivity: the basic provisions of the work have been introduced to the academic process of microbiology, immunology, histology and medical biology departments of the Tashkent Medical Academy. Sphere of usage: medicine