КООРДИНАЦИОННЫЕ СОЕДИНЕНИЯ d-МЕТАЛЛОВ С КАРБОЛИНОВЫМИ АЛКАЛОИДАМИ

Аннотация

Subjects of research: alkaloids harminc and hannaline, Zn(II), Mn(II), Co(II), Cu(II), Re(IV), Mo(VI), V(V), Co(III), Cr(III), Fe(III), Ni(II). Purpose of work: To synthesize and research new coordination compounds of d-mctals with biologically active carboline alkaloids. To determine the conditions of complex formation of carbolinc alkaloids with d-mctals and their biological activity. Methods of research: chemical, physicochemical, physical. The results obtained and their novelty: For the first time a number of complexes of harmaline, harminc and its fluorine derivative were synthesized. Their properties were determined by means of electronic, IR-, PMR-spectroscopics, elementary and dcrivatographic analyses. With the help of quantum-chemical methods PM3 the energetic characteristics, bond lengths, valence angles of free ligands and their ion forms were calculated. Based on the orbital and charge control the most possible centers of localization of coordination bonds were determined. For the first time crystal structures of two novel harmaline complexes were deciphered. Phytotoxic and biological activities of synthesized compounds were determined. Scientific and practical value: Developed conditions and methods of synthesis of complex compounds can be used as the bases for practical purpose oriented syntheses of similar coordination compounds along with prediction of properties and structure of coordination compounds of d-mctals with alkaloid derivatives. The results of quantum-chemical analysis of ligands and for the first time obtained by means of X-ray analysis crystal characteristics of novel coordination compounds can be used as reference information. Determined biological activity of synthesized coordination compounds denotes to their possible use for development of substances with anti-cancer activity. Degree of embed and economical efficiency: Obtained experimental data have been used in educational process at the department of inorganic and analytical chemistry of National University of Uzbekistan. Application field: inorganic chemistry, coordination chemistry, agriculture, medicine.