Клиникопатогенетическое значение различных типов аллергических реакций при вирусном гепатите В

Аннотация

Subjects of research: 40 patients with acute viral hepatitis В (AVHB) and 120 patients with chronic viral hepatitis В (CVHB) Purpose of work: Study clinical and pathogenic significance of allergic reactions of various types in transition of VHB in lingering andchronic course Methods of research: Clinical, laboratory, allcrgologic, immunologic, statistical. The results obtained and their novelty: Allergic hereditary family diseases. Allergy to antibiotics and insects bites occur more frequently in patients with A VHB. Unlike patients with AVHB and other forms of CVHB patients with high activity of CVHB more frequently suffer from food allergy and infectious and allergic diseases. Clinical manifestations of allergy dominated among patients with high activity of CVHB. Allergic reactions of the 1st type (anaphylactic type) developed chiefly in patients with AVHB, reactions of the Ilnd (cytotoxic reactions), Hird (Artus phenomenon) and IVth (reaction of delayed type) types were typical for patients with CVHB. Pathogenic importance of the allergic reactions of the Ilnd, Illrd and IVth types in forming of lingering course of the disease. Kctotifcn was effective in complex treatment of patients with AVHB and CVHB with high activity of pathological process in liver. Practical value: Detection of markers of the Ilnd (index of neutrophils damage), Illrd (circulating immune complexes) and IVth (reaction of inhibition of leukocytes migration) can be considered as prognostic criterion for transition of VHB into lingering course. It is expedient to include ketotifen, preparation exerting a direct antiallergic and mediated hcpatoprotective effects, in the treatment of patients with AVHB and high activity of CVHB. Degree of embed and economic effectivity: Obtained results were introduced in the clinic of Research Institute of epidemiology, microbiology and infectious diseases, Republican children hospital for infectious diseases of Karakalpakstan and in the course of studies of Tashkent Medical Academy and Nucus branch of Tashkent pediatric medical institute. . Methodical appliance on the thesis data "Viral hepatitis B, D, C and E" and information letter were published (Nucus, 2005) and sent to the corresponding institutions. Economical efficiency for 1 patient amounts to 5000 sum. Sphere of usage? medicine Fied of application: Infectious hospitals, medical departments in villages, family polyclinics.