ЦИКЛОАРТАНОВЫЕ ГЛИКОЗИДЫ ASTRAGALUS UNIFOLIOLATUS BUNGE

Аннотация

Subjects of the inquiry: Roots and above the ground parts of Astragalus unifoliolatus Bunge. Aim of the inquiry: Isolation and study of the cycloartanc glycosides from the plant Astragalus unifoliolatus Bunge, screening the biological activity of the isolated substances and extract from plant material. Method of the inquiry: extraction, chromatography methods, chemical, physical and spectral methods of investigation. The results achieved and their novelty: Tritcrpcnc compounds of the plant Astragalus unifoliolatus Bunge, growing in the Republic of Karakalpakstan have been studied. 7 triterpenoid compounds have been isolated from the plant, 4 of them are novel. The biological tests have been showed the less toxicity, cholagoguc and hypocholesteremic actions of the ethanol extract from the studied plant. The cytotoxic properties of the components from above the ground parts of Astragalus unifoliolatus Bunge were also determined. Practical value: The biological investigations showed that the high effective medicines for hepatology practice may be created on basis of the extract from the studied plant. Degree of embed and economical effectivity: The plant Astragalus unifoliolatus Bunge, growing in the Republic of Karakalpakstan is a rich source of cycloartanc glycosides. Sphere of usage: The extract from above the ground parts of Astragalus unifoliolatus Bunge containing the sum of cycloartanc glycosides may have interest in perspective as medicinal preparation for treatment hcpatologic diseases and for creation of the high specific antitumor drugs. Chemical structures of the novel glycosides, cyclounifoliosides А, В, C and D, their physical constants and spectral parameters arc included in M. I. Isaev’s hand-book «Cycloartane triterpenoids and glycosides» published in Springer.