ОСОБЕННОСТИ ИЗМЕНЕНИЙ В ОБМЕНЕ ВЕЩЕСТВ И НЕКОТОРЫЕ АСПЕКТЫ ПАТОГЕНЕЗА ПРИ СМЕШАННЫХ КИШЕЧНЫХ ПАРАЗИТОЗАХ

Аннотация

Subject of research: 128 children with parasitic diseases. Purpose of work: to study peculiarities of intestinal mixt parasitic diseases in children talking into consideration functional and metabolic state of liver, development of endogenic intoxication and optimize methods of complex treatment. Methods of research: clinical, laboratory, biochemical and statistical methods. The results obtained and their novelty: Peculiarities of clinical course of mixed intestinal parasitic diseases in children of young school age (7-14 years old) in comparison with monoinvasions were studied. Role of metabolic shifts in functional disorder in liver and development of endogenic intoxication was shown. Disorders in various stages of lipid metabolism in mono-and mixed parasitic diseases in children arc characterized in details. Pathogenetic significance of POL processes and increase of level of medium molecular peptides in development of endogenic intoxication in mixed intestinal parasitic diseases was proved. Revealing of lymphocytes bound tissue antigens of intestine and liver improves understanding of pathogenetic mechanisms of intestinal mono-and mixed parasitic diseases. Expediency of cinnarix application in complex treatment of children with mixed intestinal parasitic diseases is proved. Practical value: The thesis is of theoretical and practical significance. The character of disorders in protein, carbohydrate and lipid metabolism had been determined. The level of endogenic intoxication in patients with mixed intestinal parasitic diseases is detected allowing to work out a corresponding medicinal correction. Degree of embed and economic effectivity: Obtained results were introduced in the RIEMID hospital, Research Institute of Virology of Ministry of Public Health, in teaching at Tashkent medical academy. Economic efficiency amounted in ave-rajc to 36000 sum. Field of application: medicine, outpatients polyclinics and hospitals.