Технология отхаркивающего эликсира с антисептическим свойством

Аннотация

Subjects of research: subjects of research are the medicinal plants: radix Althaeae, flores Chamomillae, flores Achilleae millefolium, herba equiseti, folia Juglantis rediae, folia Salviae, herba Taraxaci, aethanol and purified water. Purpose of work: development of composition and technology of “Tonzilat” elixir. With expectorant, anti inflamatori, antiseptic action on the base of local raw materials. Conducting of its quality control, standardization, study of its stability and bioavailability. Methods of research: spirituose extract was obtained by means of maceration-circulation method from medicinal plants; spirit consentration was determined by means Of method, density-by means of picnometer, pl l-by means of potentiometric method, refractometric parameter-by means of Abbe refractometer dry residue of elixir in accordance with XI edition of SPh USSR. Bioavailability of preparation was studied in “vivo” experiments. Identity and assay of elixir active substances was determined with CMS (Chromatomassspectrometry) THC, SPh methods; storage term of elixir was established with “native” method (in ordinary condition). The results obtained and their novelty: Optimal composition and rational technology of “Tonzilat” elixir were developed on the base of conducted researches Bioavailability of “Tonzilat” elixir suggested was determined in “in vivo” experiments. Storage condititions and terms of “Tonzilat” elixir were established. Practical value: Projects of laboratory regalement and TPP (TPA) for “Tonzilat” elixir were developed on the base of results of researches conducted Degree of embed and economic efficiency: TPP (TPA) developed for “Tonzilat” medicinal elixir was introduced into projects of laboratory regalement. Technology of “Tonzilat” elixir successfully probed in LLC “Galenika”which gave an agreement for introduction of this preparation into industrial manufacture on its base. Field of application: pharmaceutical industry, medicine.