THE ROLE OF INFLUENCE OF THE MAIN CYTOKINES OF THE IMMUNE SYSTEM IN CHILDREN WITH PAPILLOMATOSIS OF THE LARYNX ON THE BACKGROUND OF ANTIVIRAL THERAPY

Аннотация

The purpose of the study was to study the role of cytokines and major interferons in children with laryngeal papillomatosis in the dynamics of antiviral therapy in the postoperative period. To achieve this goal, 252 children with laryngeal papillomatosis aged 3 to 9 years were examined. All children were examined and treated in the surgical department of otolaryngology of TMA. In order to determine the effectiveness of the treatment of children, the following division into groups was carried out: Group I - children with a continuously recurrent course of papillomatosis of the larynx were divided into two subgroups: Subgroup I - the comparison group received standard treatment surgery + IFN preparations (reaferon) - one course per 28 days; Subgroup I - study group surgery + IFN preparations (alpha-IFN / inosine) - according to the scheme for 1 year. Group II - children with a frequently relapsing course of PH: II a subgroup - received standard treatment surgery + IFN preparations (reaferon) - one course for 28 days; II in the subgroup - surgery + IFN preparations (alpha-IFN / inosine) - according to the scheme for 6 months. Group III - children with a rarely recurrent course of PH: III a group - surgery; Group III - surgery + licopid. It was revealed that the analysis of the main interferons and cytokines of the immune system made it possible to establish that the changes obtained in a comparative analysis of clinical variants of laryngeal papillomatosis are amenable to immunotropic therapy, which is expressed by the use of an antiviral drug. Moreover, there is an improvement in the values of cytokines and interferons, which is expressed in a decrease in the production of pro-inflammatory cytokines and in an increase in the production of IFN-α and IFN-γ, which have pronounced antiviral properties. The clinical result of therapy was a Volume 03 Issue 08-2023 39 International Journal of Medical Sciences And Clinical Research (ISSN – 2771-2265) VOLUME 03 ISSUE 08 PAGES: 39-51 SJIF IMPACT FACTOR (2021: 5. 694) (2022: 5. 893) (2023: 6. 184) OCLC – 1121105677 Publisher: Oscar Publishing Services Servi decrease in the number of recurrences of papillomatosis in children, an improvement in general well-being, and clinical and laboratory indicators of the disease. KEYWORDS papillomatosis of the larynx in children, interferons, cytokines, interleukins, interferon inducers.