IMPACT OF THE DRUG REOMANNISOL IN THE MODEL OF AN EXPERIMENTAL DIABETIC FOOT

Аннотация

The aim of the study was to learn of the effect of the new drug "Reomannisol" on wound healing, taking into account pathomorphological aspects in the complex treatment of experimental diabetic foot syndrome. Material and methods. An experimental study was carried out on 140 outbred male rats weighing 220-250 g, kept in the TMA vivarium. The experimental animals were divided into 4 groups: the 1st group was intact; 2nd group – the creation of an experimental model of alloxan diabetes mellitus; 3rd control group - against the background of alloxan diabetes, the creation of an experimental model of a diabetic foot using traditional complex treatment; 4th experimental group - on an experimental model of diabetic foot - traditional treatment and reomannisol. On the skin of each rat’s right hind paw’s footpad, a full-thickness rectangular wound measuring 2 mm×5 mm was created with a scalpel. Every day, the wounds were treated with the traditional method of treatment (5% alcohol solution of iodine and levomekol ointment) until the end of the experiment, for the experimental group, the local traditional method of treatment and intraperitoneal administration of the new Reomannisol preparation were used 1 time per day at a dose of 1 ml of Reomannisol per 100 g of animal body weight for 5 days. Results. By the 10th day in the experimental group, an independent almost complete closure of the wound defect and hair growth around the wound was noted. In the control group, on the 10th day, a wound defect of about 4.9 ± 0.05 mm2 remained, the wound healed on the 14th day of the experiment. Volume 03 Issue 11-2023 65 International Journal of Medical Sciences And Clinical Research (ISSN – 2771-2265) VOLUME 03 ISSUE 11 PAGES: 65-88 SJIF IMPACT FACTOR (2021: 5. 694) (2022: 5. 893) (2023: 6. 184) OCLC – 1121105677 Publisher: Oscar Publishing Services Servi Conclusion: The use of local treatment and reomannisol can enhance angiogenesis in the early stages of the experiment and restore disturbed microcirculation, increase macrophage response, fibroblast proliferation, maturation and remodeling of granulation tissue and its epithelization, reduce the inflammatory reaction, which leads to more effective and early healing of the wound area. KEYWORDS Experimental model of diabetic foot, experimental animals, diabetes mellitus, alloxan, surgical debridement, reomannisol.