Роль продуктов перекисного окисления липидов и противовоспалительных цитокинов крови в развитии заболеваний полости рта при гипотиреозе

Аннотация

Clinico-laboratorial part of the work is based on a survey of 96 patients with chronic generalized perio-dontitis (CGP). 22 people of the patients have chronic generalized periodontitis mild (HGPM), patients with chronic generalized periodontitis average degree (HGPA) and chronic generalized severe periodontitis (HGSP) 42 and 32 people respectively, combined with hypothyroidism. For objectification of the clinical research of the periodontal tissues, we used indicators such as the periodontal index, papillary-marginal-alveolar index and the index of Ketze. For aexact determination of the intensity of the inflammatory process used Schiller-Pisarev trial. To measure the depth of periodontal pockets also held X-ray examinations. It was found that a significant activation of lipid peroxidation and reduced antioxidant defense observed in patients with severe CGP on the background of hypothyroidism. It is shown that thyroid dysfunction occurs pro-nounced activation of the immune system, manifested by increased levels of cytokines in the serum. The highest concentration of TNF, IL-1 and IL-4 were detected in patients with moderate CGP thyroid hypofunc-tion.