AMIDE-BASED MUTUAL PRODRUG: SYNTHESIS AND EVALUATION STUDIES

Аннотация

Amide-based mutual prodrugs have gained significant attention in recent years as promising pharmaceutical candidates due to their potential to enhance drug solubility, stability, and bioavailability. This study focuses on the synthesis and evaluation of a novel amide-based mutual prodrug designed to improve the delivery and therapeutic efficacy of a parent drug. The synthesis involves the chemical conjugation of two active moieties through an amide bond to form a single prodrug entity. The evaluation encompasses a comprehensive assessment of physicochemical properties, in vitro release kinetics, enzymatic hydrolysis, and pharmacological activity of the prodrug compared to the parent drug. The results obtained shed light on the prodrug's potential advantages and challenges, providing valuable insights for further optimization and development. The findings of this study contribute to the growing body of knowledge on amide-based mutual prodrugs and their application in pharmaceutical research. KEYWORDS Amide-based mutual prodrug, synthesis, evaluation, drug delivery, solubility, stability, bioavailability, physicochemical properties, in vitro release kinetics, enzymatic hydrolysis, pharmacological activity, pharmaceutical research.