NEW WAY SCOPING OF TECHNOLOGY FOR OBTAINING BACTERICIDAL AND WOUNDING OINTMENT

Аннотация

In medical practice, for the prevention and treatment of various diseases, anti-inflammatory, antimicrobial and regenerative herbal medicines are widely used. The healing properties of medicinal plants are due to active or pharmacologically active substances - alkaloids, glycosides, saponins, tannins, enzymes, vitamins, hormones, phytoncides, etc. They are the most valuable, although they are contained in plants in minimal quantities. The article presents the results of obtaining a bactericidal, wound-healing ointment based on a dry extract of celandine herb, propolis and sea buckthorn oil. KEYWORDS Dry extract, celandine herb, technology, ointment, propolis, sea buckthorn oil. Volume 02 Issue 04-2022 61 American Journal Of Applied Science And Technology (ISSN – 2771-2745) VOLUME 02 ISSUE 04 Pages: 61-67 SJIF IMPACT FACTOR (2022: 6. 108) OCLC – 1121105677 METADATA IF – 5.582 Publisher: Oscar Publishing Services Servi INTRODUCTION celandine herb was standardized according to the requirements of the State Pharmacopoeia XI and Herbal medicinal products, due to their versatile according to the VFS project for a dry extract of activity, low toxicity and good digestibility, occupy an celandine herb. important place in world practical medicine. At the same time, special attention should be paid to the use Dry extracts obtained from medicinal plants are the of accessible, cultivated and natural sources of raw basis for creating a new drug. materials, promising in terms of implementation on Currently, combined ointments are used to enhance the basis of created technologies for new the therapeutic efficacy and expand the action. preparations from them. Known anti-inflammatory and wound-healing One of these plants is celandine herb, which has long ointment containing oil extract of plant components, been used in medical practice and has versatile as well as honey, mummy, propolis and bear fat [3]. pharmacological activity: antimicrobial, antiviral, anti- inflammatory, immunomodulatory, choleretic, This tool requires long-term use and is not used in the antispasmodic, antitumor, analgesic, which treatment of colpitis, in addition, it contains a scarce determines the prospects for further study and raw material - bear fat. development of new drugs based on it [1 -2]. In medicine, celandine is used in the form of various The aim of this work is the development of a dosage forms: water extracts, tinctures, juice from a bactericidal, wound-healing ointment with a wide fresh plant, ointments, suppositories. spectrum of therapeutic action based on a combination of a dry extract of celandine herb, sea The main active ingredients of celandine are a buckthorn oil and propolis. complex of alkaloids, which is represented by compounds with different chemical structures and Sea buckthorn oil, obtained from sea buckthorn fruits pharmacological activity. Quantitatively, by extraction with vegetable oil. It has an analgesic, benzphenanthridines chelidonine (0.3-1.0%), anti-inflammatory, antibacterial effect, is a homohelidonine (0.3-4%), sanguinarine (0.2 0.4%) and multivitamin and antitumor agent, accelerates the chelerythrine (0.1-0.3%) prevail, in smaller quantities granulation of epithelialization of tissues (with contain protopins-protopin (0.2-0.4%) and frostbite, thermal, chemical and radiation burns, allokryptopin (0.1%) and protoberberines - berberine gynecological inflammatory diseases, colpitis, vitamin (0.1-0.3%), coptisine (0.2%), etc. deficiency, hemorrhoids, pulpitis, periodontal disease). The anti-burn and repair activity of the oil is At A. Sultanov Chemical-Pharmaceutical Research due to the presence of β-sitosterol and other Institute, a technology for obtaining a dry extract of triterpenoids. celandine herb was developed. To obtain a dry extract of celandine herb, celandine herb presented by the Propolis is very rich in biologically active substances. Research Institute "Eastern Medicine" was used. The amount of phenolic compounds is not less than Methods have been developed to obtain a dry extract 25.0%. Propolis has analgesic properties, therefore it is from celandine herb. The obtained dry extract of widely used in apitherapeutic treatment in various Volume 02 Issue 04-2022 62 American Journal Of Applied Science And Technology (ISSN – 2771-2745) VOLUME 02 ISSUE 04 Pages: 61-67 SJIF IMPACT FACTOR (2022: 6. 108) OCLC – 1121105677 METADATA IF – 5.582 Publisher: Oscar Publishing Services Servi forms, both in pure form and in preparations (tablets, The quality of the ointment was assessed according to suppositories, ointments, etc.). the following indicators: appearance, homogeneity, authenticity, pH of the aqueous extract of the Experimental part. ointment, physicochemical stability and the norm of permissible deviations in the mass of the ointment. Getting a dry extract of celandine herb. Crushed dry herb of celandine in an amount of 300 g is loaded into The prepared ointment is a homogeneous mass of a container eq