Синтез и стандартизация координационных соединений магния с некоторыми производными пиридина

Аннотация

Subject of research: substances of nicotinic acid, nicodinc and pyridoxine hydrochloride, magnesium oxide and magnesium salts MgCL2 • 6H2O; Mg(NC>3)2 • •6H2O; Mg (CNS)2 • 4 H2 O. Purpose of work: search of optimal ways for single-minded synthesis, study of structure and physico-chemical properties of new coordination compounds of magnesium salts with nicotinic acid, nicodinc and pyridoxine hydrochloride, as well as standardization of complex compounds by physico-chemical methods and study of pharmacopocial indices for development and approval of the NTD for the investigated substances. Methods of research: dcrivatography, roentgenophase analysis, TLC, HPLC, UV-spcctropho tome try, A AC, IR-spcctroscopy. The results obtained and their novelty: synthesis and systematic research of 7 coordination compounds have been carried out. The most pharmacologically active ones have been revealed among them. As a result of element analysis a formation of different complexes has been established and their individuality has been proven by methods of dcrivatography, roentgenophase analysis and their principal physicochemical properties were characterized. Practical value: low toxic and high effective preparations of Magnicom, Magdine and Pyramag were offered. The developed analytical methods and performed physico-chemical investigations allow establishing a scientific and methodological basis for analysis of the medicinal agents, obtained on the base of coordination compounds of magnesium with biologically active organic ligands. Degree of embed and economic affectivity: the projects of PPP for the substances of Magnicom, Magdine were submitted for consideration to the Head Department of drug and medical equipment quality control under the Ministry of Health of the Republic of Uzbekistan. Field of application: pharmaceutical industry and medicine.