Коморбидное течение ишемической болезни сердца и хронической обструктивной болезни легких: сочетанные звенья патогенеза

Аннотация

It has been established that in patients with a combined course of coronary disease and chronic ob-structive pulmonary disease a mutually aggravating course consists in an elevation of the intensity of the processes of a free radical lipid oxidation at the expense of an increase of the level of malonic aldehyde with a diminished functioning of the system of the antioxidant defence (a decresed activity of catalase, an in-creased level of ceruloplasmin, a decreased of the lysis of low molecular proteins and the collagenolytic ac-tivity of the blood plasma. It has been corroborated that a growth of the level of endothelin–1 is the principal component of detected pathogenic transformations