Особенности изменений процессов перекисного окисления липидов при гематурических нефритах

Аннотация

The aim of this work was to study the clinical and laboratory features of current capilarotoxic nephritis in children with disorders of lipid peroxidation process definition and rationale of antioxidant therapy. Total patients with acute nephritis was 54, of which - CN (capilarotoxic) - 40 primary GN (hematuric nephritis) -14. Patients with acute GN examined during the detailed clinical manifestations and dynamics. We have ana-lyzed lipid peroxidation indices in blood and urine in different clinical forms hematuric nephritis (CN, GN), depending on the course (acute, chronic), clinical syndromes and renal function. Further, in as acute GN primary and secondary KH we compared the relationship of lipid peroxidation of clinical syndromes. When primary GN nephritic syndrome in blood and urine, and the DC level (P <0.001) was increased at the same syndrome secondary CN only in urine. Nitrogenous bases content in urine was increased in nephritic syn-drome primary GN, both in blood and in urine at capilarotoxic nephritis (P <0.001). Thus, acute GN parallel processes of lipid per oxidation change of renal functional impairment: in patients with signs of renal failure is characterized by the highest performance POL, which is explained by deep morphological changes in the kidneys.97-100.