Изучение влияния мелатонина на желчевыделительную функцию печени при экспериментальном дексаметазоновом диабете

Аннотация

The influence of melatonin on the functional state of the hepatobiliary system with dexamethasone-induced diabetes mellitus was studied. The analysis of numerous research studies made it possible to talk about the high prevalence of complications in diabetes as a disease of the liver, the principal organ of metabolic processes in the body. It was established during the experiment that diabetes reduced the intensity of bile, the number of total bilirubin in it, mainly due to its conjugated forms, cholates and cholesterol, which disturbed the relationship between the components of the bile. The injection of melatonin at a dose of 10 mg / kg intraperitoneally during 10 days lead to an increase in the intensity of bile secretion, increase the concentration of bilirubin in it, both general and conjugate fractions, cholates and cholesterol, improved the processes of conjugation, normalized cholate – cholesterol coefficient.