Взаимозависимость процессов липопероксидации и антиоксидантной защиты у животных разного возраста в условиях ранней и поздней политравмы

Аннотация

The experiment model of polytrauma of animals 3, 6, 24-month old was conducted according to the method of A.A. Hudyma. The research was conducted after 1, 3, 24 hours and for 14 days after modulation of polytrauma. The activity of processes of lipid peroxidation was judged by the content of TBK-active products. Activity of superoxide dismutase, catalase and the content of ceruloplasmin was determined by biochemical methods. Statistic processing of material was carried out by parametric methods. The analysis of the relation-ship between the two features in the presence of a normal distribution was estimated by the results of the corre-lation analysis by Pearson. We have established the relationship between lipid peroxidation and AOS in three-month young rats in the early stages after the polytraumatic modeling. At 1, 3 and 24 hours after the polytrau-matic modeling, lipid peroxidation indexes increased and enzymes of AOS were activated. In late terms after the modeling of polytrauma (14 days) in animals of 3 months old AOS protection was absent by the established direct strong correlation between the activity of SOD of the liver and blood CP (r= 0,73, р0,05). In 6 and 24-month old rats, after 1, 3, and 24 hours after polytraumaticsmodeling, there were found inverse statistically significant correlation connections between MDA level and AOS indicators. In the late stages of the modeling of polytrauma of animals of 6 and 24 months old there was a depletion of enzymatic link of AOS on the back-ground of high content of MDA. The increase of intensification of lipid peroxidation processes leads to a de-crease in the adaptation resources of AOS in animals of different age groups with polytrauma and vice versa, increase in exhaustion of the AOS potential leads to activation of lipid peroxidation which induces peroxidation processes in polytrauma. It predicts the progressing of misbalance in antioxidant system in injured animals in different terms of polytrauma.