Молекулярно-генетические маркеры и особенности течения хронической hcv-инфекции в Узбекистане

Аннотация

The aim of the study was a comparative analysis of the genotypic variants of the TNF-α and CTLA-4 genes in patients with chronic hepatitis C and liver cirrhosis and their effect on the course of the disease. The analysis of the influence of the genotypes of the TNF-α gene on the course of the disease indicates an increased risk of CVD with both moderate and highly active course of the disease in carriers of the combination of geno-types G / A + A / A. The obtained data allow us to conclude that the carriage of the allele "G" and the combina-tion of the A / G + G / G genotypes of the -49GG polymorph of the CTLA-4 gene are associated not only with a decrease in the risk of development of HCVF, but also with a lower intensity of inflammation and fibrosis in the liver and a high probability favorable course of the disease.