Динамика развития адреналиново-кальциевого повреждения сердца у крыс-самцов

Аннотация

It was investigated in the dynamics the development of necrotic and proliferate processes in the adrena-line-calcium models of heart injury in rats. It is accompanied by oxidative, carbonyl, nitrooxidative stress, in-creased oxidative modification of proteins and changes in antioxidant defense. Maximal increase of oxidative modification of protein products observed after 3 days, the nitrite anion – after 3 and 14 days, diene, triene conjugate and Schiff-base – after 7 days, TBA-active products – after 14 days. Antioxidant protection of the heart muscle increases significantly in the development of adrenaline and calcium models of heart damage and its individual links peak at different periods of research: activity of catalase – after 3 days, ceruloplasmin con-centration and peroxidase activity of blood – after 14 days, superoxide dismutase activity – after 21 days. The values of the glutathione system in all periods of the study are decreased