Прогностическая значимость клиникометаболических показателей и влияние инфра-R излучателей на исходы перитонитов

Аннотация

Subjects of the research: 1066 patients with peritonitis. Purpose of the research: improvement of the results of treatment of the patients with peritonitis by determination of the prognostic significance of clinical-metabolic parameters in the estimation of severity of patients condition, flow and outcome of the disease. Methods used in the research: clinical, microbiological, biochemical methods of investigation, mathematical statistics and mathematical modeling. Results obtained and their novelty 1. The prognostic significance of clinical-anamnestic, microbiological, laboratorial- instrumental and metabolic data has been determined on the basis of the correlational interrelation between metabolic parameters and bacterial contamination in patients with peritonitis 2. When the actions of NIDE (UIDI) RC and GI are studied in clinical conditions it is shown, that their combined application during the operation and postoperative periods considerably decreases the culture growth in peritoneal exudates and improves metabolic parameters. 3. On the basis of the method of mathematical modeling, programs arc proposed to estimate the severity of patient s condition and predictability of flow, the outcome of disease in the patients with peritonitis. Practical significance 1. The special features of the disturbance of metabolic parameters dependent on the bacterial contamination have been established, which makes it possible to reveal the patients with high risk of development of complications. 2. It is proven that the application of the infra-R emitters in combination with the traditional treatment in patients peritonitis contributes to more favorable flow of the disease and to reduction of postoperative complications and lethality. 3. Two programs have been created with the methods of mathematical modeling which allow: 1) To estimate severity of the patients condition on the basis of clinical-anamnestic, laboratorial- instrumental, metabolic and microbiological data; 2) To predict the complications of the disease; 3) To predict the healing of the postoperative wound; 4) To identify the indications for NIDE (UIDI) applications. Level of induction: method of application of narrow-spectrum infrared distant emitters in peritonitis is used in surgical department of the Clinical Hospital of Emergencies and Casualties, Г' Municipal Clinic Hospital and in Central Military Clinical Hospital named after P.F. Borovskiy. Region application: Surgery.