Повышение эффективности лечения больных железодефицитной анемией путем индукции синтеза и метаболизма гема в печени

Аннотация

Objects of research: 92 immature rats with term of 30-40 days. 108 patients with asiderotic an anemia: men - 13 (12%), women - 95 (88%); middle age - 39,9 years. The control group was made by 17 healthy persons. The purpose of work: Increase of efficiency of treatment of patients asiderotic [iron-deficiency] anemia by an induction of synthesis and a metabolism a theme in a liver. Methods of research: clinical, biochemical, morphological, tool. The received results and their novelty: Activization of the initial stages of synthesis is established on models alimentary asiderotic [iron-deficiency] anemia in mitochondrial and microsomal-cytosol fractions of a liver a theme, on a background to inhibit its final stage. Correction of a level malonic dialdehyde and activity of enzymes superoxide dismutase (SOD) and catalase (CAT) is revealed as a result of application of a combination of preparations maltofcr and neosclcn in mitochondrial and microsomal-cytosol fractions of a liver of experimental animals. For the first time we analyse parameters of ions of tri valent, bivalent iron both dif-feritin in mitochondrial and microsomal-cytosol fractions of a liver of experimental animals. The morphological picture of a liver at alimentary iron deficiency is submitted an anemia and correction of the revealed infringements by preparations maltofcr and ncosclcn. For the first time on the big clinico-expcrimcntal material efficiency of application of a combination of preparations maltofer and neoselen is shown. The practical importance: Application of a combination of preparations maltofer and neoselen on a clinico-experimental material restores activity of enzymes of synthesis and disintegration a theme in hepatocyte’s, improves ferroki-nctic, hematologic parameters and promotes improvement of a functional condition of a liver. The received positive results in clinical researches have found acknowledgement (confirmation) on an experimental material that allows to recommend the given circuit of treatment железодефицитной to an anemia in clinical and outpatient conditions. Degree of introduction and economic efficiency: Results of research are introduced into practice гематологического, therapeutic branches, and as for doctors of an initial link. Scope: hematology, therapy.