Цитокиновые механизмы в поздний период развития экспериментального бактериально-иммунного пародонтита

Аннотация

The article presents the results of research of the cytokine link of immune system in the experimental animals -white rats, which were determined by the level of proinflammatory and anti-inflammatory cytokines in blood serum of the intact animals and on the 30th day for experimental periodontitis development. For that characterised changes of the cytokine mechanism more expressed in a late stage of the experimental bacterial-immune periodontitis. In particular, in the period of chronic inflammatory response, on the 30th day of the study, were increased concentrations of IL-ip and TNF-a, while the IL-10, IL-4 content decreased in these conditions. At that, the ratio of pro- and antiinflammatory cytokines (IL-13 / IL-10) as an important indicator of the immune response was increased. Based on these results, it was proved that the formation of the pathological process in the periodontal complex is accompanied in a result of imbalance in the cytokinogenesis system for the late period of the inflammatory response development, that evidence their leading role in the regulation of the immune-inflammatory response in this modeled pathological process.