Therapeutic Fasting and Its Effects on Cognitive Function and Neuroplasticity Dmytro Stepanenko

Аннотация

Therapeutic fasting attracts growing interest SUBMITED 11 April 2025 within neuroscience because metabolic stress ACCEPTED 27 May 2025 modulates neurotrophic signalling. The present study PUBLISHED 30 June 2025 VOLUME Vol.07 Issue 06 2025 evaluates intermittent fasting combined with vegan nutrient patterns for their cumulative influence on CITATION memory, attention and synaptic plasticity. A systematic Dmytro Stepanenko. (2025). Therapeutic Fasting and Its Effects on examination of experimental rodents, controlled human Cognitive Function and Neuroplasticity. The American Journal of Applied trials and molecular investigations conducted. Brain- Sciences, 7(06), 31–36. https://doi.org/10.37547/tajas/Volume07Issue06-06 derived neurotrophic factor (BDNF), AMP-activated kinase and sirtuin pathways were selected as COPYRIGHT mechanistic markers. Evidence synthesis indicates that © 2025 Original content from this work may be used under the terms alternate-day energy restriction up-regulates of the creative commons attributes 4.0 License. hippocampal BDNF, while polyphenols and omega-3 precursors supplied by plant diets reinforce this response. Clearance of misfolded proteins, attenuation of neuro-inflammation and stabilisation of neuronal membranes surfaced as convergent mechanisms. Comparative evaluation suggests superior cognitive performance when fasting protocols coincide with plant-rich menus compared with either intervention alone. The analysis highlights translational gaps, particularly long-term human data, and formulates directions for personalised nutritional neuromodulation. Potential safety considerations related to hypoglycaemia and micronutrient sufficiency are critically appraised within cohorts. The article will be useful for clinical nutritionists, neuroscientists, geriatric practitioners and policymakers. Keywords: intermittent fasting, vegan diet, neuroplasticity, brain-derived neurotrophic factor, The American Journal of Applied Sciences 31 https://www.theamericanjournals.com/index.php/tajas The American Journal of Applied Sciences cognition, autophagy, omega-3 precursors, polyphenols, framing homocysteine-linked cognition. J. Gudden [3] sirtuin signalling, memory enhancement. analysed intermittent fasting trials with neurocognitive read-outs, supplying comparative effect sizes. A. Brocchi Introduction: Neurodegenerative disorders impose a [1] investigated metabolic imaging during fasting, growing burden because global longevity steadily rises supporting interpretation of brain energetics. A. while pharmacological breakthroughs remain scarce. Katonova [4] probed vegan diet influence on Dietary manipulation delivers a feasible preventive Alzheimer’s trajectories, reinforcing epidemiological avenue: intermittent energy restriction activates sections. adaptive metabolic cascades, and plant-centred menus supply anti-inflammatory micronutrients. The present Comparative synthesis juxtaposed effect magnitudes investigation targets this dietary interface. across intervention categories. When homogeneous metrics existed, Hedges g was pooled through random- The aim involves assessment of synergistic cognitive effects meta-analysis executed in R (metafor package). outcomes arising when therapeutic fasting converges Narrative integration connected mechanistic findings with vegan nutrient provision. Three analytical tasks with behavioural data. Strength-of-evidence grading structure the work: followed GRADE recommendations. 1) Pathway interrogation — to map molecular