INTERPLAY OF RENAL HISTOPATHOLOGY, BLOOD UREA NITROGEN, AND CREATININE LEVELS IN RATS WITH UNILATERAL URETERAL OBSTRUCTION: A COMPREHENSIVE ANALYSIS

Аннотация

This study investigates the intricate relationship between renal histopathology, blood urea nitrogen (BUN), and creatinine levels in rats subjected to unilateral ureteral obstruction (UUO). A comprehensive analysis was conducted to discern the interplay among these factors and understand the implications for renal function. Rats with induced UUO were closely monitored, and renal tissues were examined for histopathological alterations. Simultaneously, BUN and creatinine levels were measured to assess renal dysfunction. The results revealed a complex interdependence, shedding light on the nuanced connections between structural changes, biomarker levels, and the severity of renal impairment in the context of UUO. This comprehensive analysis contributes valuable insights to our understanding of renal pathophysiology and lays the groundwork for potential therapeutic interventions. KEYWORDS Renal histopathology, blood urea nitrogen, creatinine levels, unilateral ureteral obstruction, renal dysfunction, biomarkers, rat model, nephropathy, kidney pathology, comprehensive analysis.