Researcher, Center for the Development of Professional Qualifications of Medical Workers, Uzbekistan M.B. Urinov Researcher, Medical association Karmaninsky district, Navoi region, Uzbekistan O.Kh. Parmanov

Аннотация

INTRODUCTION outcome, and response to treatment also in many Until recently, in the diagnosis and treatment of cases depend on the gender of the patient (2,7). many diseases, including neurological ones, the gender factor was not given much importance. The real boom in the study of the problem of sex Stud-ies on the effects of new drugs have often differences began about 10 years ago, after the been conducted only on male volunteers, and the widespread introduction of magnetic reso-nance specific effects of their effects on the female body imaging into practice, when morphological have been overlooked (4). Many publications did differences in the brain were discovered in men not indicate the gender of the subjects, while others and women. Physicians, scientists, psychologists deliberately excluded women to maintain the and sociologists have presented a general picture “purity of the experiment” (8). At the same time, that points to clear sexual differentiation (3). experience shows that some dis-eases are more However, there is very little research on this common in men, while others are more common in problem in neurological diseases. women (1,6). The severity of the disease, its It is known that there are initial characteristics of https://www.theamericanjournals.com/index.php/tajmspr 40 THE USA JOURNALS THE AMERICAN JOURNAL OF MEDICAL SCIENCES AND PHARMACEUTICAL RESEARCH (ISSN – 2689-1026) VOLUME 06 ISSUE04 cognitive and psy-chological functions in men and depending on gender. This problem remains women. The psychological profile of men and completely undeveloped. women is different. Accordingly, there are The purpose of our study was to analyze the behavioral differences be-tween men and women. relationship between the nature of cognitive These differences result in men and women impairment, balance and walking disorders in perceiv-ing the same influences and reacting patients with CCI in terms of sexual dimorphism. differently to the same situation (1,6). This is also reflected in neuroscience. A general pattern is that METHODS higher levels of anxiety and depression are found We examined 96 patients with CCI due to cerebral in women across a range of illnesses (9,10). atherosclerosis, who were divided into male (50 From the point of view of the problem of sexual patients) and fe-male (46 patients) groups. The dimorphism, chronic cerebral ischemia (CCI) is of groups were comparable in age (mean age 66.4 particular interest. It is known that with CCI, the so- years), all patients had moderate cognitive called “triad of frontal dysfunction” (FTD) impairment. They were as-sessed using the MMSE develops, including cog-nitive, locomotor and scales and the Frontal Dysfunction (FTD) Battery emotional disorders (depression). The clinical (5). Motor abnormalities were assessed using the signs of FTD are interrelated, and common Tinetti test (10). The ob-tained data were mechanisms of vascular and degener-ative brain processed using mathematical cross-correlation damage, mainly the frontal lobes and their analysis. Statistical differences between groups connections with the deep structures of the brain, were assessed using the Wilcoxon test. play a role in their genesis. Considering the The average results for the tests studied are numerous morphofunctional differences in the presented in Table 1, from which it can be seen that brain between men and women, it can be assumed there are significant differences between men and that the structure within the FTD has its own women with CCI. First of all, attention is drawn to gender characteristics in CCI. This is important the presence of sig-nificant differences between both from the point of view of further the sexes on all three scales, with greater understanding the differences between the male preservation of cognitive and locomotor functions and female brain, and for the development of in females. differentiated approaches to the treatment of CCI Table 1. Indicators of tests of cognitive and locomotor impairments in CCI in men and women Tests Whole M F R≤ (M:F) group Tinetti: - total score 19,45 17,5 21,4 0,05 - balance 11,6 10,4 12,8 - - walking 7,85 7,1 8,6 0,05 FTD 13,45 12,9 14,0 0,01 MMSE: https://www.theamericanjournals.com/index.php/tajmspr 41 THE USA JOURNALS THE AMERICAN JOURNAL OF MEDICAL SCIENCES AND PHARMACEUTICAL RESEARCH (ISSN – 2689-1026) VOLUME 06 ISSUE04 - total score 26,0 25,1 26,9 0,01 - verbal functions 6,05 5,1 7,0 0,05 - non-verbal functions 20,0 19,9 - secondly, there are differ-ences in the nature of the Against this background, some features of the relationships between the tests studied and their results were revealed when compared by subtests subtests. They consist in the fact that in the group within the tests used. In particular, no significant of men, positive correla-tions between the Tinetti dif-ferences were found in the “balance” subtests of test and the verbal component of the MMSE test, as the Tinetti test and “non-verbal func