Ключевые слова: Разработать комплекс лечебных мероприятий при дети, различных поражениях слизистой оболочки полости рта у слизистая оболочка детей с хроническим вирусным гепатитом С

Аннотация

Ключевые слова: Разработать комплекс лечебных мероприятий при дети, различных поражениях слизистой оболочки полости рта у слизистая оболочка детей с хроническим вирусным гепатитом С. Для решения полости рта, задач и достижения целей проводились исследования хронический вирусный гепатит, общеклинические, биохимические, иммунологические, вирусологическая, микробиологические, вирусологические, стоматологические патология. и статистические. В работе использовались методы исследования. Исследование проводилось в период с 2018 по 2021 годы. Сбор данных осуществлялся на базе Республиканского специализированного научно- практического медицинского центра педиатрии МЗ РУз (отделение хронических гепатитов. Зав. кафедрой является академик АН РУз Иноятова Ф.И.), а также на базе детской стоматологической поликлиники Ташкентского государственного стоматологического института. Сформирована основная группа больных, включающая 112 детей с ВГС и патологией ХОБЛ. Результаты: Анализ показал, что предложенный способ лечения оказал достоверное положительное влияние на состояние слизистой оболочки полости рта у детей с гепатитом С. THE PURPOSE OF THE STUDY To develop a set of therapeutic measures for various lesions of the oral mucosa in children with chronic viral hepatitis C. Material and methods. The main group of patients was formed, including 112 children with HCV and OM pathology. The data of 50 children with OM pathology without HCV markers were used as a comparison group. The groups of patients were comparable by gender, no statistical differences were found (p>0.05). Boys predominated in both groups (66% in the main 35 Profilaktik tibbiyot va salomlatlik– Профилактическая медицина и здоровье– Preventive Medicine and Health Issue –1 № 1 (2022) / ISSN 2181-3663 group and 62% in the control group). In the main group, the proportion of girls was 34%, in the control group – 38%. The main group was dominated by children aged 7-14 years and 14-18 years (27.7% and 68.7%, respectively). In the control group, younger children were more often registered. There were significantly fewer adolescent children (14-18 years old) – 2% (p<0.001). All children included in this study underwent a comprehensive examination, including an assessment of the state of liver function, determination of immunological and virological markers of chronic hepatitis C, as well as a comprehensive dental examination, including, in addition to standard dental examination indicators, microbiological and immunological examinations of the oral fluid. We analyzed the frequency of dental pathology recorded in children with chronic hepatitis C, depending on the CHC genotype. The data obtained are presented in Figure 1.1. 100 90 87,8 90 80 80 aphtosus stomatitis 68,7 70 herpangina 60 acute candidasis stomatitis 50 50 хр гиперпл кандидоз afta Bednara 40 syndrome Shegrene 28,3 30 географ язык 20 20 20 15,1 xerostomiya 10 10 7,1 10 4 5 0 0 1genotype 3 genotype From the data in Figure 4.9. it can be seen that there were no significant differences in the frequency of registration of various dental nosologies. At the same time, it should be noted that in our study there were very significant differences between the number of patients with different virus genotypes. Thus, there were only 2 patients with genotype 2, 10 children with genotype 3, while genotype 1b was detected in 100 children. In this regard, our results cannot fully reflect the dependence of the frequency of development of various types of dental disorders in children with chronic hepatitis C depending on the virus genotype. We analyzed the frequency of development of dental pathology depending on the activity of the process in the liver. The results obtained are shown in Figure 1.1. It can be seen from the diagram data that in patients with a high degree of activity of the pathological process in the liver, the frequency of registration of all nosological types of pathology of the oral mucosa was significantly higher compared to patients with moderate and minimal degree of activity of chronic hepatitis C. 36 Profilaktik tibbiyot va salomlatlik– Профилактическая медицина и здоровье– Preventive Medicine and Health Issue –1 № 1 (2022) / ISSN 2181-3663 83,3 83,3 66,7 0 highth 100 16,7 66,7 50 xerostomiya geographicai tongue 87,5 66,1 syndrome Shegren 10,7 moderate 1,8 Afta Bednar 16,1 10,7 chronic herpetic stomatitis 1,8 23,2 acute candidiasis stomatitis 88 herpangina 72 0 aphtosus stomatitis 0 minimal 14 2 2 30 0 20 40 60 80 100 120 RESEARCH RESULTS With chronic hepatitis C, xerophthalmia and geographic stomatitis were detected significantly more often (p<0.001) (90.2% and 69.6%, respectively), and a number of diseases were recorded that were not observed in the control group, namely, herpangina (0.9%), Bednar’s afta (0.9%), Sjögren’s syndrome (5.4%). The first study reporting an association between salivary gland disease and hepatitis C was published in 1992 and showed that 57% of patients with chronic liver di