Влияние стеарата натрия на минеральный обмен в организме белых крыс

Аннотация

Experiments were performed under the conditions of a subacute experiment on 28 white male rats weigh-ing 160-180 g, divided into 4 groups. The first group was the control. The following three doses were adminis-tered to the animals of the three following animals daily for 30 days: the 2nd group - 1/50 of LD 50 (200.0 mg / kg), the 3rd - 1/250 of LD 50 (40.0 mg / kg), the 4th, 1/2500 of LD 50 (4.0 mg / kg). The content of trace elements was determined on an atomic adsorption spectrophotometer using standard techniques. As a result of the ex-periment, it was found that the dynamics of changes in the concentration of potassium, sodium and calcium ions in the tissues of experimental animals was multidirectional and depended on the amount of sodium stea-rate in the body of animals. The substance in a dose of 1/50 from LD 50 (200.0 mg / kg) adversely affected the mineral metabolism in the body of experimental rats, as evidenced by a significant increase in calcium against the background of decreasing the amount of potassium and sodium in the kidney and brain tissue, as well as a decrease in calcium and growth of potassium and sodium in the liver tissue. These changes develop as a result of the influence of surfactants and are one of the causes and reflection of dismetabolic phenomena characteris-tic of the cells of the body under the toxic effects of xenobiotics.