РОЛЬ АНТИФОСФОЛИПИДНОГО СИНДРОМА В ПРИЧИНАХ РЕПРОДУКТИВНЫХ ПОТЕРЬ

Аннотация

This article provides an overview of scientific studies and their results on miscarriage, miscarriage, the role of antiphospholipid syndrome in preterm birth. According to the conclusions of domestic and foreign authors, the improvement of the principles of pregravid preparation is of unsurpassed importance in the prevention of complications of the antiphospholipidsyndrome. Key words: fetoplacental system, antiphospholipid syndrome, reproductive losses, hemostasis,hypoxia, malnutrition. РОЛЬАНТИФОСФОЛИПИДНОГО СИНДРОМА ВПРИЧИНАХ РЕПРОДУКТИВНЫХПОТЕРЬ Аннотация. В этой статье представлен обзор научных исследований и их результатов, касающихся невынашивания беременности, невынашивания беременности, роли антифосфолипидного синдрома в преждевременных родах. Согласно выводам отечественных и зарубежных авторов, совершенствование принципов прегравидарной подготовки имеет непревзойденное значение в профилактике осложнений антифосфолипидного синдрома. Ключевые слова: фетоплацентарная система, антифосфолипидный синдром, репродуктивныепотери,гемостаз,гипоксия,недостаточноепитание. Actuality. Inability to bear a pregnancy is one of the most common obstetric pathologies among women in the world, and in recent years, a large number of scientific researches have been carried out to prevent this pathology, the development of childbirth complications and reproductive losses in pregnancy. is devoted to the identification of high-risk groups. According to the World Health Organization (WHO), infertility is 7-10% of all pregnancies in developed countries, and 15-20% in developing countries. Antiphospholipid syndrome and disorders of the hemostasis system in women who are unable to bear pregnancy, improvement of the principles of pregravidarum training in order to prevent reproductive losses based on the study is one of the serious problems that need tobe solved today. At the world level, a number of scientific researches are being carried out in order to achieve high efficiency in terms of thecauses, course and results of treatment tactics of infertility 797 International scientific journal ISSN: 2181-3906 «MODERN SCIENCE АND RESEARCH» 2023 VOLUME2/ISSUE12/UIF:8.2/MODERNSCIENCE.UZ in women. In particular, to assess the role of antiphospholipid antibodies in the development of disorders of the hemostasis system from the first period of pregnancy and their effect on local blood flow, the formation of functional disorders ofthe placental system; to determine the role of antiphospholipid syndrome and its markers in predicting and early diagnosis of dysfunction of the fetoplacental system; The development of modern methods of measures to reduce disability and death among pregnant women complicated by normal miscarriage remains the priority of scientificresearch. The results obtained from the scientific research carried out so far at the world level have revealed the role of antiphospholipid syndrome in the inability to bear a pregnancy. It was found that the appearance of antiphospholipid autoantibodies, including IgC and IgM-type antibodies b2-glycoprotein, in the blood of a pregnant woman leads to the inability tocarry a pregnancy [13, 24-30 b; 23, 1032-1036 b]. According to modern views, AFS contributes to activation of hemostasis thrombocyte connection, violation of hemostatic potential and increase of endothelial damage. Such changes have a negative effect on the formation of infarct zones, ischemia of the chorion with villi, disruption of the utero-placental system, development of hypoxia and hypotrophy inthe fetus, as well as thedevelopment of thefetus [21, 126-127b; 22,31b]. The aim of the study is to achieve early diagnosis and reduction of reproductive losses based on studying the characteristics of the hemostasis system and fetoplacental blood circulation system in pregnant women with antiphospholipid syndrome. Material andmethods Methods such as general clinical-laboratory, biochemical examination, determination of hemostasiogram, functional-diagnostic examinations (UTT examination), statistical analysis were used in theresearch. Results andanalyses The practical significance of the research is that the obtained results, developed scientific conclusions are useful in the implementation of complex treatment measures for the biochemical status of women with normal miscarriage, as well as early diagnosis of the risk factors of reproductive losses, prepregnancy preparation in women with biochemical markers. , it is explained by conducting pregnancy according to an improved algorithm, carrying out complex medical measures on time, increasing the effectiveness of treatment and improving the quality of life. The scientific significance of the results of the research is that as a result of determining the anamnestic, biochemical, condition of women with inability to bear pregnancy, AFA, β2- glycoprotein, volchanic anticoagulants contribute to the development of normal miscarriage and early diagnosis and prognosis of reproductive